Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-4-12
pubmed:abstractText
The Schizosaccharomyces pombe septation initiation network (SIN) signals the onset of cell division from the spindle pole body (SPB) and is regulated by the small GTPase Spg1p. The localization of SIN components including Spg1p to the SPB is required for cytokinesis and is dependent on Sid4p, a constitutive resident of SPBs. However, a direct interaction between Sid4p and other members of the SIN has not been detected. To understand how Sid4p is linked to other SIN components, we have begun to characterize an S. pombe homolog of the Saccharomyces cerevisiae SPB protein Nud1p. We have determined that this S. pombe Nud1p homolog corresponds to Cdc11p, a previously uncharacterized SIN element. We report that Cdc11p is present constitutively at SPBs and that its function appears to be required for the localization of all other SIN components to SPBs with the exception of Sid4p. The Cdc11p C terminus localizes the protein to SPBs in a Sid4p-dependent manner, and we demonstrate a direct Cdc11p-Sid4p interaction. The N-terminus of Cdc11p is required for Spg1p binding to SPBs. Our studies indicate that Cdc11p provides a physical link between Sid4p and the Spg1p signaling pathway.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10330408, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10339566, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10409726, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10459013, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10679389, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10749924, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10769201, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10775265, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10799520, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10805785, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10837231, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-10929710, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-11101520, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-11166217, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-11514632, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-11676915, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-1527180, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-1587485, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-1655416, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-1741305, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-2005825, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-3477553, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-7583641, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-7785336, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-8039497, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-8422996, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-8422997, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-8978031, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-9182664, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-9203579, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-9251043, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-9420333, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-9571234, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-958201, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-9649519, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-9717240, http://linkedlifedata.com/resource/pubmed/commentcorrection/11950932-9742395
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CDC11 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases, http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Methyltransferases, http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/SPB1 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Schizosaccharomyces pombe Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Sid4 protein, S pombe, http://linkedlifedata.com/resource/pubmed/chemical/TRM2 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/tRNA Methyltransferases
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1059-1524
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1203-14
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11950932-Temperature, pubmed-meshheading:11950932-Fungal Proteins, pubmed-meshheading:11950932-Saccharomyces cerevisiae Proteins, pubmed-meshheading:11950932-Epitopes, pubmed-meshheading:11950932-Precipitin Tests, pubmed-meshheading:11950932-Amino Acid Sequence, pubmed-meshheading:11950932-Protein Binding, pubmed-meshheading:11950932-Deoxyribonucleases, pubmed-meshheading:11950932-Molecular Sequence Data, pubmed-meshheading:11950932-Nuclear Proteins, pubmed-meshheading:11950932-Protein Structure, Tertiary, pubmed-meshheading:11950932-Methyltransferases, pubmed-meshheading:11950932-Cloning, Molecular, pubmed-meshheading:11950932-Sequence Homology, Amino Acid, pubmed-meshheading:11950932-Plasmids, pubmed-meshheading:11950932-tRNA Methyltransferases, pubmed-meshheading:11950932-Signal Transduction, pubmed-meshheading:11950932-Schizosaccharomyces, pubmed-meshheading:11950932-Cytoskeletal Proteins, pubmed-meshheading:11950932-Microtubule-Associated Proteins
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