Source:http://linkedlifedata.com/resource/pubmed/id/11937729
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2002-4-8
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pubmed:abstractText |
In this prospective study, the 24-hour gastric aspirate volume was carefully recorded before, 24 and 48 h after administering 1.7 mg/kg/8-hourly of oral erythromycin to 16 ventilated neonates less than 32 weeks of gestation. Their median gestational age was 28.5 weeks (range 23-31 weeks), their median birthweight was 1,045 g (range 690-1,560 g) and the median day of life at which erythromycin was commenced was 9.5 days (range 4-16 days). Prior to administering erythromycin median 24-hour gastric aspirate volume, expressed as a percentage of the milk volume given over the same period, was 38.5% (range 20.0-100%). It was significantly lower 24 h (median 12%, range 0-41%, p = 0.0004) and 48 h (median 5%, range 0-21%, p = 0.0004) after commencing erythromycin. There was also significant reduction of gastric aspirate volume between 24 and 48 h after commencing erythromycin (p = 0.0024). Milk volume increment over the same period was not significant (p = 0.1022). These preliminary results warrant further evaluation through a randomised controlled trial.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0006-3126
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11937729-Administration, Oral,
pubmed-meshheading:11937729-Dose-Response Relationship, Drug,
pubmed-meshheading:11937729-Enteral Nutrition,
pubmed-meshheading:11937729-Erythromycin,
pubmed-meshheading:11937729-Gastrointestinal Agents,
pubmed-meshheading:11937729-Gestational Age,
pubmed-meshheading:11937729-Humans,
pubmed-meshheading:11937729-Infant, Newborn,
pubmed-meshheading:11937729-Infant, Premature,
pubmed-meshheading:11937729-Infant, Premature, Diseases,
pubmed-meshheading:11937729-Motilin,
pubmed-meshheading:11937729-Prospective Studies,
pubmed-meshheading:11937729-Respiration, Artificial,
pubmed-meshheading:11937729-Respiratory Distress Syndrome, Newborn,
pubmed-meshheading:11937729-Stomach,
pubmed-meshheading:11937729-Suction
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pubmed:year |
2002
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pubmed:articleTitle |
Effect of low-dose oral erythromycin on gastric aspirates in ventilated neonates less than 32 weeks of gestation. Preliminary results.
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pubmed:affiliation |
NICU, 2nd Department of Paediatrics, University of Athens, Aglaia Kyriakou Children's Hospital, Greece. hdellagr@ath.forthnet.gr
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pubmed:publicationType |
Journal Article
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