Source:http://linkedlifedata.com/resource/pubmed/id/11936844
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2002-4-8
|
| pubmed:abstractText |
Because of its key role in proteosynthesis, the total content of elongation factor-2 (EF-2) and the distribution of six main EF-2 variants were investigated after Pseudomonas Exotoxin A catalyzed [37P]ADP-ribosylation using 1D-PAGE and isoelectric focusing (IEF) in a rat model of hemodynamic overload with variable degrees of cardiac hypertrophy: Chronic NO-synthase inhibition by L-NAME (N-omega-nitro-L-arginine-methyl-ester; 0.75 mg/ml drinking water) induced arterial hypertension without hypertrophy but myocardial apoptosis; additional treatment with IGF-1 (osmotic micropumps) did not modify hypertension but reduced apoptosis allowing moderate hypertrophy of the left ventricles. Total EF-2 did not significantly increase in rats with hemodynamic overload with or without IGF-1 supplementation. A positive correlation was found between an acidic EF-2 variant and apoptosis (p = 0.01). Hypertrophy under additional IGF-1 was combined with a shift of the EF-2 variants to basic subtypes (p < 0.01). This finding may be indicative of the trophic potency of IGF-1.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Elongation Factor 2
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0300-8177
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
229
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
25-34
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11936844-Animals,
pubmed-meshheading:11936844-Apoptosis,
pubmed-meshheading:11936844-Body Weight,
pubmed-meshheading:11936844-Cardiomegaly,
pubmed-meshheading:11936844-DNA Fragmentation,
pubmed-meshheading:11936844-Disease Models, Animal,
pubmed-meshheading:11936844-Enzyme Inhibitors,
pubmed-meshheading:11936844-Genetic Variation,
pubmed-meshheading:11936844-Heart,
pubmed-meshheading:11936844-Hemodynamics,
pubmed-meshheading:11936844-Hypertension,
pubmed-meshheading:11936844-Insulin-Like Growth Factor I,
pubmed-meshheading:11936844-Male,
pubmed-meshheading:11936844-Myocardium,
pubmed-meshheading:11936844-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:11936844-Nitric Oxide Synthase,
pubmed-meshheading:11936844-Peptide Elongation Factor 2,
pubmed-meshheading:11936844-Rats,
pubmed-meshheading:11936844-Rats, Wistar
|
| pubmed:year |
2002
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| pubmed:articleTitle |
The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload.
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| pubmed:affiliation |
Department of Mediicne III, Martin-Luther-University, Halle-Wittenberg, Germany. doris.jaeger@medizin.uni-halle.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|