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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0205147,
umls-concept:C0220908,
umls-concept:C0249880,
umls-concept:C0547040,
umls-concept:C0919457,
umls-concept:C1510854,
umls-concept:C1553877,
umls-concept:C1608885,
umls-concept:C1704788,
umls-concept:C1880156,
umls-concept:C1880274,
umls-concept:C2827404,
umls-concept:C2931822
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pubmed:issue |
7
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pubmed:dateCreated |
2002-4-4
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pubmed:abstractText |
Recurrent deletion on a chromosomal location in tumor cells can be detected by frequent allelic loss and generally is considered to be an indication of the existence of a tumor suppressor gene (TSG) in the region. In the current study, using fluorescent-labeled, high-density microsatellite markers for allelotyping, the authors pinpointed three minimal deleted regions (MDRs) and screened mutations of putative TSGs on chromosomes 3, 9, and 11 in nasopharyngeal carcinoma (NPC) cases occurring in Taiwan.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1987-96
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11932901-Acid Anhydride Hydrolases,
pubmed-meshheading:11932901-Alleles,
pubmed-meshheading:11932901-Chromosome Aberrations,
pubmed-meshheading:11932901-Chromosome Deletion,
pubmed-meshheading:11932901-Chromosomes, Human, Pair 11,
pubmed-meshheading:11932901-Chromosomes, Human, Pair 3,
pubmed-meshheading:11932901-Chromosomes, Human, Pair 9,
pubmed-meshheading:11932901-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:11932901-DNA, Neoplasm,
pubmed-meshheading:11932901-DNA Mutational Analysis,
pubmed-meshheading:11932901-Genes, Tumor Suppressor,
pubmed-meshheading:11932901-Humans,
pubmed-meshheading:11932901-Loss of Heterozygosity,
pubmed-meshheading:11932901-Microsatellite Repeats,
pubmed-meshheading:11932901-Nasopharyngeal Neoplasms,
pubmed-meshheading:11932901-Neoplasm Proteins,
pubmed-meshheading:11932901-Neoplasm Recurrence, Local,
pubmed-meshheading:11932901-Neoplasm Staging,
pubmed-meshheading:11932901-Polymerase Chain Reaction,
pubmed-meshheading:11932901-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11932901-Tumor Suppressor Protein p14ARF
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pubmed:year |
2002
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pubmed:articleTitle |
Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT,p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma.
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pubmed:affiliation |
Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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