Source:http://linkedlifedata.com/resource/pubmed/id/11926750
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2002-4-2
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pubmed:abstractText |
Cardiac allograft vasculopathy is the most common cause of death and retransplantation following heart transplantation, and about 10% of patients per year have evidence of accelerated vascular disease; 50% at 5 years. Cytomegalovirus (CMV) infection has been associated with accelerated cardiac vasculopathy and decreased 5-year survival. Prophylactic therapy using ganciclovir has reduced the incidence of CMV disease, but not in the group at highest risk, namely the seronegative recipient of an allograft from a seropositive donor (D+/R-). Combination prophylaxis consisting of CMV hyperimmune globulin (CMV-IGIV) plus ganciclovir is associated with decreased intimal thickening, reduced coronary artery disease and obliterative bronchiolitis, and improved survival.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1398-2273
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
3 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
44-8
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pubmed:dateRevised |
2009-10-8
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pubmed:meshHeading |
pubmed-meshheading:11926750-Antiviral Agents,
pubmed-meshheading:11926750-Coronary Disease,
pubmed-meshheading:11926750-Cytomegalovirus,
pubmed-meshheading:11926750-Cytomegalovirus Infections,
pubmed-meshheading:11926750-Ganciclovir,
pubmed-meshheading:11926750-Graft Rejection,
pubmed-meshheading:11926750-Graft Survival,
pubmed-meshheading:11926750-Heart Transplantation,
pubmed-meshheading:11926750-Humans,
pubmed-meshheading:11926750-Immunoglobulins,
pubmed-meshheading:11926750-Risk Factors,
pubmed-meshheading:11926750-Transplantation, Homologous
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pubmed:year |
2001
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pubmed:articleTitle |
Role of cytomegalovirus in cardiac allograft vasculopathy.
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pubmed:affiliation |
University of Alabama at Birmingham, USA. dweill@uab.edu
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pubmed:publicationType |
Journal Article,
Review
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