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pubmed:abstractText |
Ocular melanin synthesis modulates rod photoreceptor production, because in albino eyes, rod numbers are reduced by approximately 30%. In this study, rod numbers and ocular rhodopsin concentrations were measured in intermediate pigmentation phenotypes to determine whether proportional reductions in melanin are correlated with proportional changes in rod numbers. Further, patterns of cell production and death were examined around the time of birth, when rod production peaks, to determine whether there are abnormalities in these features associated with hypopigmentation.
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