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11909713
Source:
http://linkedlifedata.com/resource/pubmed/id/11909713
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0039736
,
umls-concept:C0085387
,
umls-concept:C0243071
pubmed:issue
7
pubmed:dateCreated
2002-3-22
pubmed:abstractText
Thalidomide showed cyclooxygenase (COX)-1/2 inhibitory activity with a potency comparable to that of aspirin. Structural development studies of thalidomide resulted in potent COX-1/2 inhibitors, and COX-1-selective and COX-2-selective inhibitors.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes
,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins
,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases
,
http://linkedlifedata.com/resource/pubmed/chemical/Thalidomide
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0960-894X
pubmed:author
pubmed-author:HashimotoYuichiY
,
pubmed-author:NagasawaKazuoK
,
pubmed-author:NoguchiTomomiT
,
pubmed-author:ShimazawaRumikoR
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1043-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11909713-Cyclooxygenase 1
,
pubmed-meshheading:11909713-Cyclooxygenase 2
,
pubmed-meshheading:11909713-Cyclooxygenase 2 Inhibitors
,
pubmed-meshheading:11909713-Cyclooxygenase Inhibitors
,
pubmed-meshheading:11909713-Humans
,
pubmed-meshheading:11909713-Inhibitory Concentration 50
,
pubmed-meshheading:11909713-Isoenzymes
,
pubmed-meshheading:11909713-Membrane Proteins
,
pubmed-meshheading:11909713-Molecular Structure
,
pubmed-meshheading:11909713-Prostaglandin-Endoperoxide Synthases
,
pubmed-meshheading:11909713-Structure-Activity Relationship
,
pubmed-meshheading:11909713-Substrate Specificity
,
pubmed-meshheading:11909713-Thalidomide
pubmed:year
2002
pubmed:articleTitle
Thalidomide and its analogues as cyclooxygenase inhibitors.
pubmed:affiliation
Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
pubmed:publicationType
Journal Article
,
Research Support, Non-U.S. Gov't