Source:http://linkedlifedata.com/resource/pubmed/id/11905547
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2002-3-21
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pubmed:abstractText |
Anti-cholinergic agents are considered the bronchodilator therapy of first-choice in the treatment of patients with stable chronic obstructive pulmonary disease (COPD) associated with heart disease since they may be as effective or more effective than inhaled beta2-agonists and, moreover, they do not interact with cardiac beta-adrenoceptors. The aim of our study was to evaluate the bronchodilator activity of oxitropium bromide in outpatients suffering from exacerbations of COPD associated with heart diseases (ischaemic heart disease and/or arrhythmias). We recruited 50 consecutive outpatients (33 males and 17 females, mean age 68.6 years, 15 current smokers and 35 ex-smokers). Each patient performed body plethismography in basal condition and 30 min after inhalation of 200 microg metered dose inhaler (MDI) oxitropium bromide administered by a device (Fluspacer). FEV1, FVC, MMEF25-75, sRaw and tRaw were evaluated. Thirty minutes after 200 microg oxitropium bromide administration, we observed a significant improvement in FEV1 11.6% +/- 1 (mean +/- SEM) (P<0.01); FVC, MMEF25-75 sRaw variation was respectively: 9.2% +/- 0.6, 31.4 +/- 2.9, -19.9 +/- 1.1. Placebo did not significantly change pulmonary function. Our data suggest that oxitropium bromide bronchodilator activity is effective in exacerbations of COPD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0954-6111
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
137-41
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11905547-Acute Disease,
pubmed-meshheading:11905547-Aged,
pubmed-meshheading:11905547-Arrhythmias, Cardiac,
pubmed-meshheading:11905547-Bronchodilator Agents,
pubmed-meshheading:11905547-Cholinergic Antagonists,
pubmed-meshheading:11905547-Double-Blind Method,
pubmed-meshheading:11905547-Female,
pubmed-meshheading:11905547-Forced Expiratory Volume,
pubmed-meshheading:11905547-Humans,
pubmed-meshheading:11905547-Male,
pubmed-meshheading:11905547-Middle Aged,
pubmed-meshheading:11905547-Myocardial Ischemia,
pubmed-meshheading:11905547-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:11905547-Scopolamine Derivatives,
pubmed-meshheading:11905547-Smoking,
pubmed-meshheading:11905547-Vital Capacity
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pubmed:year |
2002
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pubmed:articleTitle |
Bronchodilating effect of oxitropium bromide in heart disease patients with exacerbations of COPD: double-blind, randomized, controlled study.
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pubmed:affiliation |
Institute of Lung Disease, Respiratory Unit, San Paolo Hospital, University of Milan, Itlay.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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