|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2002-3-21
|
|
pubmed:abstractText |
A method for designing molecular constructions of combined artificial immunogens mimicking viral particles is proposed. Using this method, it is possible to expose antigenic determinants of any viral protein on the surface of such particles and to deliver plasmids containing genes encoding the synthesis of protein antigens to target cells. This approach was used to create the constructions of combined artificial immunogens inducing the production of specific antibodies to HIV-1 and to evaluate the extent and duration of B-cellular immune response depending on the way of antigen exposure to immunocompetent cells.
|
|
pubmed:language |
rus
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0208-0613
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
17-21
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11904919-AIDS Vaccines,
pubmed-meshheading:11904919-Animals,
pubmed-meshheading:11904919-Epitopes,
pubmed-meshheading:11904919-Gene Products, env,
pubmed-meshheading:11904919-Gene Products, gag,
pubmed-meshheading:11904919-HIV-1,
pubmed-meshheading:11904919-Immunization,
pubmed-meshheading:11904919-Mice,
pubmed-meshheading:11904919-Mice, Inbred BALB C,
pubmed-meshheading:11904919-Plasmids,
pubmed-meshheading:11904919-Vaccines, Combined,
pubmed-meshheading:11904919-Vaccines, Synthetic
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
[Molecular construction of experimental combined vaccines].
|
|
pubmed:affiliation |
Institute for Designing and Technology of Bioactive Substances, Berdsk, Novosibirsk Region.
|
|
pubmed:publicationType |
Journal Article,
English Abstract
|
