Source:http://linkedlifedata.com/resource/pubmed/id/11895757
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2002-3-15
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| pubmed:abstractText |
Recently we have identified subgroups of de novo primary diffuse large B-cell lymphoma (DLBCL) based on complementary DNA microarray-generated gene expression profiles. To correlate the gene expression profiles with cytogenetic abnormalities in these DLBCLs, we examined the occurrence of the t(14;18)(q32;q21) in the 2 distinctive subgroups of DLBCL: one with the germinal center B-cell gene expression signature and the other with the activated B cell-like gene expression signature. The t(14;18) was detected in 7 of 35 cases (20%). All 7 t(14;18)-positive cases had a germinal center B-cell gene expression profile, representing 35% of the cases in this subgroup, and 6 of these 7 cases had very similar gene expression profiles. The expression of bcl-2 and bcl-6 proteins was not significantly different between the t(14;18)-positive and -negative cases, whereas CD10 was detected only in the group with the germinal center B-cell expression profile, and CD10 was most frequently expressed in the t(14;18)-positive cases. This study supports the validity of subdividing DLBCL into 2 major subgroups by gene expression profiling, with the t(14;18) being an important event in the pathogenesis of a subset of DLBCL arising from germinal center B cells. CD10 protein expression is useful in identifying cases of DLBCL with a germinal center B-cell gene expression profile and is often expressed in cases with the t(14;18).
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:AlizadehAsh AAA,
pubmed-author:ArmitageJames OJO,
pubmed-author:ChanWing CWC,
pubmed-author:GreinerTimothy CTC,
pubmed-author:HuangJames ZJZ,
pubmed-author:LevyRonaldR,
pubmed-author:LossosIzidore SIS,
pubmed-author:LynchJames CJC,
pubmed-author:PickeringDiane LDL,
pubmed-author:SangerWarren GWG,
pubmed-author:StaudtLouis MLM,
pubmed-author:WarnkeRoger ARA,
pubmed-author:WeisenburgerDennis DDD
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2285-90
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11895757-Chromosome Mapping,
pubmed-meshheading:11895757-Chromosomes, Human, Pair 14,
pubmed-meshheading:11895757-Chromosomes, Human, Pair 8,
pubmed-meshheading:11895757-DNA Fingerprinting,
pubmed-meshheading:11895757-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11895757-Gene Rearrangement,
pubmed-meshheading:11895757-Genes, bcl-2,
pubmed-meshheading:11895757-Humans,
pubmed-meshheading:11895757-Lymphoma, B-Cell,
pubmed-meshheading:11895757-Polymerase Chain Reaction,
pubmed-meshheading:11895757-Translocation, Genetic
|
| pubmed:year |
2002
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| pubmed:articleTitle |
The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile.
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| pubmed:affiliation |
Department of Pathology, The Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE 68198, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|