Linked Life Data

11890964

Source:http://linkedlifedata.com/resource/pubmed/id/11890964

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pubmed-article:11890964pubmed:abstractTextAgouti protein is an endogenous antagonist of melanocortin receptors (MCR), including MCR3 and MCR4, which have been implicated as part of the hypothalamic mechanism that mediates leptin-induced hypophagia. In this experiment we examined the effects of peripheral and central leptin administration in male and female beta-actin promoter (BAPa) mice that express agouti protein ectopically and have a phenotype that includes obesity and diabetes which is exaggerated in males compared with females. Intraperitoneal infusion of 10 microg leptin/day for 13 days caused weight loss and a transient inhibition of food intake in wild-type mice, with a greater effect in males than females. Male BAPa mice were resistant to leptin infusion whereas female mice lost weight. All of the mice lost body weight following a single intracerebroventricular injection of leptin but the effect was greater in female BAPa mice than any other group. There also was a delayed suppression of food intake that was the same for wild-type and BAPa female mice, whereas food intake recovered faster in BAPa than wild-type males. The dissociation between food intake and body weight loss implies a significant effect of leptin on energy expenditure in BAPa mice. These results demonstrate that the effect of leptin on energy balance is not entirely dependent upon the melanocortin system.lld:pubmed
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pubmed-article:11890964pubmed:authorpubmed-author:HarrisRuth...lld:pubmed
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pubmed-article:11890964pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:11890964pubmed:articleTitleLeptin responsiveness in mice that ectopically express agouti protein.lld:pubmed
pubmed-article:11890964pubmed:affiliationDepartment of Foods and Nutrition, University of Georgia, Dawson Hall, Athens, GA 30605, USA. harrisrb@arches.uga.edulld:pubmed
pubmed-article:11890964pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11890964pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:11890964pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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