Source:http://linkedlifedata.com/resource/pubmed/id/11890964
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2002-3-13
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| pubmed:abstractText |
Agouti protein is an endogenous antagonist of melanocortin receptors (MCR), including MCR3 and MCR4, which have been implicated as part of the hypothalamic mechanism that mediates leptin-induced hypophagia. In this experiment we examined the effects of peripheral and central leptin administration in male and female beta-actin promoter (BAPa) mice that express agouti protein ectopically and have a phenotype that includes obesity and diabetes which is exaggerated in males compared with females. Intraperitoneal infusion of 10 microg leptin/day for 13 days caused weight loss and a transient inhibition of food intake in wild-type mice, with a greater effect in males than females. Male BAPa mice were resistant to leptin infusion whereas female mice lost weight. All of the mice lost body weight following a single intracerebroventricular injection of leptin but the effect was greater in female BAPa mice than any other group. There also was a delayed suppression of food intake that was the same for wild-type and BAPa female mice, whereas food intake recovered faster in BAPa than wild-type males. The dissociation between food intake and body weight loss implies a significant effect of leptin on energy expenditure in BAPa mice. These results demonstrate that the effect of leptin on energy balance is not entirely dependent upon the melanocortin system.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Agouti Signaling Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/nonagouti protein, mouse
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0031-9384
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
75
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
159-67
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11890964-Agouti Signaling Protein,
pubmed-meshheading:11890964-Animals,
pubmed-meshheading:11890964-Blood Glucose,
pubmed-meshheading:11890964-Body Composition,
pubmed-meshheading:11890964-Body Weight,
pubmed-meshheading:11890964-Brain Chemistry,
pubmed-meshheading:11890964-Diabetes Mellitus,
pubmed-meshheading:11890964-Eating,
pubmed-meshheading:11890964-Female,
pubmed-meshheading:11890964-Genotype,
pubmed-meshheading:11890964-Infusions, Parenteral,
pubmed-meshheading:11890964-Injections, Intraventricular,
pubmed-meshheading:11890964-Insulin,
pubmed-meshheading:11890964-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11890964-Leptin,
pubmed-meshheading:11890964-Male,
pubmed-meshheading:11890964-Mice,
pubmed-meshheading:11890964-Mice, Inbred Strains,
pubmed-meshheading:11890964-Obesity,
pubmed-meshheading:11890964-Phenotype,
pubmed-meshheading:11890964-Protein Biosynthesis,
pubmed-meshheading:11890964-Proteins,
pubmed-meshheading:11890964-Sex Characteristics
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| pubmed:articleTitle |
Leptin responsiveness in mice that ectopically express agouti protein.
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| pubmed:affiliation |
Department of Foods and Nutrition, University of Georgia, Dawson Hall, Athens, GA 30605, USA. harrisrb@arches.uga.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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