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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-3-4
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pubmed:abstractText |
We have previously shown in healthy volunteers that an amino acid mixture lacking tyrosine and phenylalanine reduces tyrosine availability to the brain and produces cognitive and neuroendocrine effects consistent with reduced dopamine function. This could provide a potential nutritional approach to disorders such as mania and schizophrenia, which are characterised by overactivity of dopamine pathways. The amino acid mixture we tested previously is unpalatable, whereas mixtures containing only branch chain amino acids can be made more palatable. However, the effects of such mixtures on dopamine function in humans have not been studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
160
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
192-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11875637-Adult,
pubmed-meshheading:11875637-Amino Acids, Branched-Chain,
pubmed-meshheading:11875637-Cross-Over Studies,
pubmed-meshheading:11875637-Dopamine,
pubmed-meshheading:11875637-Dose-Response Relationship, Drug,
pubmed-meshheading:11875637-Double-Blind Method,
pubmed-meshheading:11875637-Female,
pubmed-meshheading:11875637-Humans,
pubmed-meshheading:11875637-Male,
pubmed-meshheading:11875637-Middle Aged,
pubmed-meshheading:11875637-Neuropsychological Tests,
pubmed-meshheading:11875637-Pattern Recognition, Visual,
pubmed-meshheading:11875637-Phenylalanine,
pubmed-meshheading:11875637-Prolactin,
pubmed-meshheading:11875637-Recognition (Psychology),
pubmed-meshheading:11875637-Space Perception,
pubmed-meshheading:11875637-Time Factors,
pubmed-meshheading:11875637-Tryptophan,
pubmed-meshheading:11875637-Tyrosine
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pubmed:year |
2002
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pubmed:articleTitle |
A dose-finding study on the effects of branch chain amino acids on surrogate markers of brain dopamine function.
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pubmed:affiliation |
University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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