Linked Life Data

11867016

Source:http://linkedlifedata.com/resource/pubmed/id/11867016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-2-27
pubmed:abstractText
Treatment with combination antiretroviral therapy has transformed the natural history of human immunodeficiency virus (HIV) infection. Effective antiretroviral therapy results in both reduced risk of cytomegalovirus (CMV) disease and prolonged survival following CMV disease. These effects seem to be mediated by the reconstitution of immune responses against CMV, which results in re-established host control of CMV replication. As a result, some individuals have been able to discontinue maintenance therapy for CMV with a low risk of disease recurrence to date. The risk of development or progression reappears in the context of antiretroviral failure--a problem increasingly recognized in clinical practice. However, improved immune function is not always beneficial. Indeed, previously uncommon inflammatory complications have been associated with immune reconstitution following highly active antiretroviral therapy. The natural history of CMV disease at a time of rapid changes in treatment strategies remains uncertain and, therefore, individuals at risk continue to require careful management.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0969-7667
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Changing trends in cytomegalovirus disease in HIV-infected patients.
pubmed:affiliation
Department of Virology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK. j.deayton@rfc.ucl.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't