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rdf:type |
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lifeskim:mentions |
umls-concept:C0003360,
umls-concept:C0034650,
umls-concept:C0034869,
umls-concept:C0037925,
umls-concept:C0242697,
umls-concept:C0680242,
umls-concept:C0871261,
umls-concept:C1140675,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
1977-2-24
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pubmed:abstractText |
1 The effects of some antihistamines on the lobster muscle fibre and the frog spinal cord were investigated using intracellular and extracellular recordings, respectively. 2. On lobster muscle, histamine H1-blockers reversibly antagonized responses to bath-applied glutamate, aspartate and quisqualate but not responses to gamma-aminobutyric acid (GABA). Iontophoretic glutamate potentials were also reduced. Histamine (up to 1 mM) had no effect on this preparation. 3 The H1-antagonists produced a small increase in muscle membrane conductance and a slight hyperpolarization. These effects were largely unchanged in a low C1- bathing solution. Procaine (1 mM) decreased membrane conductance and did not affect responses to GABA or glutamate. 4 The H2-antagonist burimamide blocked both glutamate and GABA-evoked responses on the lobster muscle without affecting resting potential or conductance. 5 In the frog cord, bath-applied histamine produced ventral root depolarizations and dorsal root hyperpolarizations (sometimes biphasic responses). These effects were reduced by tetrodotoxin (TTX) but not by antazoline (H1-blocker) or burimamide; the latter reversibly antagonized responses to both glutamate and GABA on TTX-treated cords while antazoline was ineffective. 6 It is suggested that antihistamines can act as non-specific amino acid antagonists by interacting at the level of the receptor-coupled ionophores.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-1086111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-1086112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-1122397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-1139319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-1174946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-1177094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-1202198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-1256640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-13062231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-13599117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-14035890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-14165167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-167156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-237236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-241888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4133689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4145193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4153889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4302133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4346988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4356518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4387307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4401751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4405559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4437737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-4844460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-5924114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-6051794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-813800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11863-823069
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
583-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11863-Amino Acids,
pubmed-meshheading:11863-Animals,
pubmed-meshheading:11863-Chlorides,
pubmed-meshheading:11863-Evoked Potentials,
pubmed-meshheading:11863-Glutamates,
pubmed-meshheading:11863-Histamine H1 Antagonists,
pubmed-meshheading:11863-Muscle Contraction,
pubmed-meshheading:11863-Muscles,
pubmed-meshheading:11863-Nephropidae,
pubmed-meshheading:11863-Spinal Cord,
pubmed-meshheading:11863-gamma-Aminobutyric Acid
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pubmed:year |
1976
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pubmed:articleTitle |
Antagonism by some antihistamines of the amino acid-evoked responses recorded from the lobster muscle fibre and the frog spinal cord.
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pubmed:publicationType |
Journal Article,
In Vitro
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