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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5559
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pubmed:dateCreated |
2002-2-22
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pubmed:abstractText |
The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons. Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, with Brn-1(-/-)/Brn-2(-/-) mice exhibiting cortical inversion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cdk5 activator p39,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 5,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/POU Domain Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Pou3f3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/neuronal Cdk5 activator (p25-p35),
http://linkedlifedata.com/resource/pubmed/chemical/reelin protein,
http://linkedlifedata.com/resource/pubmed/chemical/transcription factor Brn-2
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
295
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1528-32
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11859196-Animals,
pubmed-meshheading:11859196-Brain,
pubmed-meshheading:11859196-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:11859196-Cell Line,
pubmed-meshheading:11859196-Cell Movement,
pubmed-meshheading:11859196-Cerebral Cortex,
pubmed-meshheading:11859196-Cyclin-Dependent Kinase 5,
pubmed-meshheading:11859196-Cyclin-Dependent Kinases,
pubmed-meshheading:11859196-Extracellular Matrix Proteins,
pubmed-meshheading:11859196-Female,
pubmed-meshheading:11859196-Gene Targeting,
pubmed-meshheading:11859196-Hippocampus,
pubmed-meshheading:11859196-Homeodomain Proteins,
pubmed-meshheading:11859196-In Situ Hybridization,
pubmed-meshheading:11859196-Male,
pubmed-meshheading:11859196-Mice,
pubmed-meshheading:11859196-Mutation,
pubmed-meshheading:11859196-Nerve Tissue Proteins,
pubmed-meshheading:11859196-Neurons,
pubmed-meshheading:11859196-Neuropeptides,
pubmed-meshheading:11859196-POU Domain Factors,
pubmed-meshheading:11859196-Serine Endopeptidases,
pubmed-meshheading:11859196-Trans-Activators,
pubmed-meshheading:11859196-Transcription, Genetic,
pubmed-meshheading:11859196-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Transcriptional regulation of cortical neuron migration by POU domain factors.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0648, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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