| pubmed-article:11850721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11850721 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:11850721 | lifeskim:mentions | umls-concept:C0221912 | lld:lifeskim |
| pubmed-article:11850721 | lifeskim:mentions | umls-concept:C0150647 | lld:lifeskim |
| pubmed-article:11850721 | lifeskim:mentions | umls-concept:C1524066 | lld:lifeskim |
| pubmed-article:11850721 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:11850721 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11850721 | pubmed:dateCreated | 2002-2-18 | lld:pubmed |
| pubmed-article:11850721 | pubmed:abstractText | Biological effects of in vivo transfection of a potential anti-inflammatory gene, designated Sm16, cloned from the human parasite Schistosoma mansoni were analyzed in these studies. A single intradermal injection of a full-length cDNA of Sm16 resulted in the expression of Sm16 in the epidermis, dermis, skin migratory cells and skin-draining lymph nodes of mice for up to 7 days. Subsequently the anti-inflammatory effect of this gene expression was evaluated by inducing an inflammatory response in the skin of mice. These studies showed that Sm16 gene delivery resulted in a significant suppression of cutaneous inflammation as shown by a reduction in cutaneous edema, decrease in neutrophil infiltration, suppression of pro-inflammatory cytokine expression and down-regulation of ICAM-1 expression in the skin inflammatory site. Cells collected from the skin-draining lymph nodes showed reduced proliferation to mitogen. Multiple intradermal injection of Sm16 cDNA failed to induce any antibody response in mice for up to 8 weeks after initial injection. These findings suggest a potential for developing Sm16 gene delivery as a therapeutic agent for treating inflammatory skin disorders. | lld:pubmed |
| pubmed-article:11850721 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11850721 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11850721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11850721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11850721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11850721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11850721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11850721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11850721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11850721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11850721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11850721 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11850721 | pubmed:issn | 0969-7128 | lld:pubmed |
| pubmed-article:11850721 | pubmed:author | pubmed-author:RamaswamyKK | lld:pubmed |
| pubmed-article:11850721 | pubmed:author | pubmed-author:YehEE | lld:pubmed |
| pubmed-article:11850721 | pubmed:author | pubmed-author:RaoK V NKV | lld:pubmed |
| pubmed-article:11850721 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11850721 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:11850721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11850721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11850721 | pubmed:pagination | 38-45 | lld:pubmed |
| pubmed-article:11850721 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11850721 | pubmed:meshHeading | pubmed-meshheading:11850721... | lld:pubmed |
| pubmed-article:11850721 | pubmed:meshHeading | pubmed-meshheading:11850721... | lld:pubmed |
| pubmed-article:11850721 | pubmed:meshHeading | pubmed-meshheading:11850721... | lld:pubmed |
| pubmed-article:11850721 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11850721 | pubmed:articleTitle | Suppression of cutaneous inflammation by intradermal gene delivery. | lld:pubmed |
| pubmed-article:11850721 | pubmed:affiliation | Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, IL 61107, USA. | lld:pubmed |
| pubmed-article:11850721 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11850721 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11850721 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11850721 | lld:pubmed |
