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pubmed-article:11849426pubmed:abstractTextNitric oxide and apoptosis in mesangial cells. Radicals such as nitric oxide (NO) or superoxide (O(-)(2)) encompass the ability to initiate morphological and biochemical alterations that are reminiscent of apoptosis. In mesangial cells, death as a result of NO formation is efficiently antagonized by the simultaneous presence of superoxide (O(-)(2)) and vice versa. This article reviews the consequences of a diffusion controlled NO/O(-)(2) interaction with the outcome of redirecting the apoptotic initiating activity of either NO or O(-)(2) toward protection. The crosstalk between cell destructive and protective pathways, and their activation or inhibition under the modulatory influence of NO and/or O(-)(2) are summarized.lld:pubmed
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pubmed-article:11849426pubmed:issn0085-2538lld:pubmed
pubmed-article:11849426pubmed:authorpubmed-author:BrüneBernhard...lld:pubmed
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pubmed-article:11849426pubmed:volume61lld:pubmed
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pubmed-article:11849426pubmed:pagination786-9lld:pubmed
pubmed-article:11849426pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11849426pubmed:year2002lld:pubmed
pubmed-article:11849426pubmed:articleTitleNitric oxide and apoptosis in mesangial cells.lld:pubmed
pubmed-article:11849426pubmed:affiliationDepartment of Cell Biology, University of Kaiserslautern, Erwin-Schrödinger-Strasse, 67663 Kaiserslautern, Germany. bruene@rhrk.uni-kl.delld:pubmed
pubmed-article:11849426pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:11849426pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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