Linked Life Data

11847186

Source:http://linkedlifedata.com/resource/pubmed/id/11847186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-2-15
pubmed:abstractText
ACE plays an important role in the regulation of arterial pressure; however, a linear relationship between ACE expression and arterial pressure has not been demonstrated. The present study employed telemetric monitoring in female transgenic mice to determine the influence of partial and complete deletion of the ACE gene on basal arterial pressure and arterial pressure responses to a high-NaCl diet. On the basal NaCl diet, 24-hour mean arterial pressure was significantly correlated with the number of functional copies of the ACE gene; ie, arterial pressure was lowest in 0-copy (80 +/- 1 mm Hg), intermediate in 1-copy (100 +/- 1 mm Hg), and highest in 2-copy (113 +/- 1 mm Hg) ACE mice. The high-NaCl diet significantly increased mean arterial pressure in 0-copy (99 +/- 1 mm Hg) and 1-copy (108 +/- 1 mm Hg) mice but not in 2-copy mice (114 +/- 1 mm Hg). These results demonstrate a copy-dependent relationship between ACE gene expression and both basal arterial pressure and arterial pressure responses to a high-NaCl diet, suggesting that either partial or complete reduction in the ACE gene can alter arterial pressure.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
214-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Blood pressure and NaCl-sensitive hypertension are influenced by angiotensin-converting enzyme gene expression in transgenic mice.
pubmed:affiliation
Vascular Biology and Hypertension Program of the Department of Medicine, University of Alabama at Birmingham, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.