Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-2-13
pubmed:abstractText
Two new pentaoxygenated xanthones, 2,3-dihydroxy-1,6,7-trimethoxyxanthone (1) and 3,6-dihydroxy-1,5,7-trimethoxyxanthone (2) were isolated from the leaf of Hypericum geminiflorum. The antiplatelet activities of the constituents, 2,6-dimethoxy-p-benzoquinone (3), gemichalcone A (4), gemichalcone B (5), and cycloartocarpin (6), of this plant, were assessed in vitro by determining their inhibitory effects on the aggregation of washed rabbit platelets induced by various inducers. The anti-inflammatory effects of 4 and 5 were assessed in vitro by determining their inhibitory effects on the chemical mediators released from mast cells and neutrophils. Of the compounds tested, 4 exhibited the most potent inhibition of platelet aggregation induced by arachidonic acid (AA) and 4 and 5 strongly inhibited the release of beta-glucuronidase and lysozyme in formyl-Met-Leu-Phe (fMLP)-stimulated rat neutrophils.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0032-0943
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11842322-Animals, pubmed-meshheading:11842322-Anti-Inflammatory Agents, pubmed-meshheading:11842322-Cell Degranulation, pubmed-meshheading:11842322-Dose-Response Relationship, Drug, pubmed-meshheading:11842322-Glucuronidase, pubmed-meshheading:11842322-Histamine, pubmed-meshheading:11842322-Hypericum, pubmed-meshheading:11842322-Mast Cells, pubmed-meshheading:11842322-Medicine, Chinese Traditional, pubmed-meshheading:11842322-Neutrophils, pubmed-meshheading:11842322-Plant Extracts, pubmed-meshheading:11842322-Platelet Aggregation, pubmed-meshheading:11842322-Platelet Aggregation Inhibitors, pubmed-meshheading:11842322-Rabbits, pubmed-meshheading:11842322-Rats, pubmed-meshheading:11842322-Rats, Sprague-Dawley, pubmed-meshheading:11842322-Superoxides, pubmed-meshheading:11842322-Xanthenes, pubmed-meshheading:11842322-Xanthones
pubmed:year
2002
pubmed:articleTitle
Antiplatelet and anti-inflammatory constituents and new oxygenated xanthones from Hypericum geminiflorum.
pubmed:affiliation
School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China. meinch@cc.kmu.edu.tw
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't