Linked Life Data

11840380

Source:http://linkedlifedata.com/resource/pubmed/id/11840380

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-2-12
pubmed:abstractText
Blood pressure reduction and angiotensin-converting enzyme (ACE) inhibitors slow but do not stop progressive decline of renal function in established diabetic nephropathy (DN), but predictors of this decline in patients undergoing these interventions are unknown. We prospectively examined patients to determine whether age, sex, ethnicity, mean blood pressure, plasma creatinine, urine protein excretion, and cigarette smoking predict renal function decline in type 2 DN treated toward the recommended mean blood pressure goal of 92 mm Hg (about 125/75 mm Hg) with antihypertensives including ACE inhibitors. Thirty-three DN patients with initial plasma creatinine less than 1.4 mg/dL were followed 64.0 +/- 1.1 months. After correcting for differences in follow-up time, demographic variables, and other relevant variables, plasma creatinine increased, indicating renal function decline despite mean blood pressure reduction to 92 +/- 1 mm Hg and administration of ACE inhibitors. Regression analysis showed that smoking was the only examined parameter that significantly predicted renal function decline. Smokers (n = 13) and nonsmokers (n = 20) had similar follow-up (61.4 +/- 2.1 months versus 65.7 +/- 1.1 months), mean blood pressure (91 +/- 1 mm Hg versus 92 +/- 1 mm Hg), and initial plasma creatinine (1.05 +/- 0.08 mg/dL versus 1.08 +/- 0.03 mg/dL). Nevertheless, follow-up plasma creatinine was higher in smokers than nonsmokers (1.78 +/- 0.20 mg/dL versus 1.32 +/- 0.04 mg/dL). The data show that renal function declines faster in smokers than nonsmokers with type 2 DN undergoing treatment to improve blood pressure including ACE inhibitors. Cigarette smoking remains a risk factor for renal function decline in type 2 DN despite currently recommended therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1523-6838
pubmed:author
pubmed:copyrightInfo
Copyright 2002 by the National Kidney Foundation, Inc.
pubmed:issnType
Electronic
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
376-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Cigarette smoking predicts faster progression of type 2 established diabetic nephropathy despite ACE inhibition.
pubmed:affiliation
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't