Source:http://linkedlifedata.com/resource/pubmed/id/11839521
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2002-12-23
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pubmed:abstractText |
G-protein coupled receptors (GPCRs) represent possibly the most important target class of proteins for drug discovery. Over 30% of clinically marketed drugs are active at this receptor family. These drugs exhibit their activity at <10% of all known GPCRs. A major challenge for the pharmaceutical industry is to associate the many novel GPCRs with disease to identify the drugs of the future. This process consists of a collection of experimental paradigms that together can be loosely labelled 'target validation'.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1359-6446
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-46
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pubmed:dateRevised |
2005-11-16
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pubmed:meshHeading |
pubmed-meshheading:11839521-Animals,
pubmed-meshheading:11839521-Computer Simulation,
pubmed-meshheading:11839521-GTP-Binding Proteins,
pubmed-meshheading:11839521-Gene Expression,
pubmed-meshheading:11839521-Humans,
pubmed-meshheading:11839521-Models, Biological,
pubmed-meshheading:11839521-Orphan Drug Production,
pubmed-meshheading:11839521-Pharmacology,
pubmed-meshheading:11839521-Receptors, Drug
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pubmed:year |
2002
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pubmed:articleTitle |
Target validation of G-protein coupled receptors.
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pubmed:affiliation |
Systems Research, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, UK SG1 2NY.
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pubmed:publicationType |
Journal Article,
Review
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