Linked Life Data

11829339

Source:http://linkedlifedata.com/resource/pubmed/id/11829339

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-2-6
pubmed:abstractText
Cerebral cortical malformations are relatively common anomalies identified by neuroimaging and pathologically in patients with epilepsy and mental retardation. A disruption in neuronal migration during central nervous system development has been postulated as the pathogenesis for many of these disorders. Recently, the cell migration hypothesis has been proven accurate for lissencephaly, subcortical band heterotopia, and periventricular nodular heterotopia. Furthermore, advances in cellular and molecular biology have begun elucidating the fundamental mechanisms underlying these migration disorders. These data have resulted in redefining and recategorizing specific malformations based on their molecular genetic abnormality. In this review we shall discuss the current understanding of neuronal migration in the developing cerebral cortex, the evaluation of these patients, and attempt to describe the pathogenesis for several well-characterized human disorders of cell migration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-3069
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Neuronal migration, cerebral cortical development, and cerebral cortical anomalies.
pubmed:affiliation
Institute for Medical Genetics, University Hospital of Wales, Cardiff.
pubmed:publicationType
Journal Article, Review