| pubmed-article:11823542 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11823542 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:11823542 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
| pubmed-article:11823542 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:11823542 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:11823542 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:11823542 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:11823542 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11823542 | pubmed:dateCreated | 2002-2-1 | lld:pubmed |
| pubmed-article:11823542 | pubmed:abstractText | Short-term combination therapy with the costimulatory antagonists CTLA4Ig and anti-CD40 ligand induces prolonged suppression of disease onset in New Zealand Black/New Zealand White F(1) systemic lupus erythematosus-prone mice. To determine the mechanism for this effect, 20- to 22-wk-old New Zealand Black/New Zealand White F(1) mice were treated with six doses each of CTLA4Ig and anti-CD40 ligand Ab over 2 wk. Combination-treated mice, but not mice treated with either agent alone, had prolonged survival and the production of pathogenic IgG anti-dsDNA Ab was suppressed. Twenty weeks after completion of treatment the frequency of activated B cells producing anti-dsDNA Ab was decreased, and the abnormal transition of T cells from the naive to the memory compartment was blocked. Combination treatment partially suppressed class switching and decreased the frequency of somatic mutations in the V(H)BW-16 gene, which is expressed by pathogenic anti-DNA Abs. Treated mice were still able to respond to the hapten oxazolone when it was given 8 wk after treatment initiation, and they mounted a somatically mutated IgG anti-oxazolone response that was noncross-reactive with dsDNA. Fifty to 60% of previously treated mice, but only 14% of previously untreated mice, responded within 2-3 wk to a second course of therapy given at the onset of fixed proteinuria and remained well for a further 3-4 mo. Although this treatment had no immediate effect on serum anti-dsDNA Abs or on the abnormal T cell activation observed in sick mice, 25% of treated mice lived for >18 mo compared with 5% of untreated controls. These results suggest that the effect of costimulatory blockade in remission induction must be mediated by a different mechanism than is demonstrated in the disease prevention studies. | lld:pubmed |
| pubmed-article:11823542 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11823542 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11823542 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11823542 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11823542 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11823542 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11823542 | pubmed:author | pubmed-author:MiharaMasahik... | lld:pubmed |
| pubmed-article:11823542 | pubmed:author | pubmed-author:WangXiaoboX | lld:pubmed |
| pubmed-article:11823542 | pubmed:author | pubmed-author:HuangWeiqingW | lld:pubmed |
| pubmed-article:11823542 | pubmed:author | pubmed-author:SinhaJayashre... | lld:pubmed |
| pubmed-article:11823542 | pubmed:author | pubmed-author:DavidsonAnneA | lld:pubmed |
| pubmed-article:11823542 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11823542 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11823542 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:11823542 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11823542 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11823542 | pubmed:pagination | 2046-53 | lld:pubmed |
| pubmed-article:11823542 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:11823542 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11823542 | pubmed:articleTitle | Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus. | lld:pubmed |
| pubmed-article:11823542 | pubmed:affiliation | Departments of. Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461. | lld:pubmed |
| pubmed-article:11823542 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11823542 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11823542 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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