Linked Life Data

11818671

Source:http://linkedlifedata.com/resource/pubmed/id/11818671

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-1-30
pubmed:abstractText
We present a case of multiple myeloma who died of liver failure 7.5 months after initial diagnosis. Postmortem liver biopsy revealed diffuse CD3-expressing plasma cell infiltration and eosinophilic amorphous material deposition which was considered as light chain deposits. T cell receptor-gamma rearrangement was not detected in liver biopsy sections using the polymerase chain reaction despite CD3 positivity. To our knowledge, this is the first report of CD3-expressing plasma cell infiltration in tissue sections. The discordance between the phenotype and the genotype suggests a partial activation of genes encoding the T cell antigens by the transforming event. We also concluded that CD3 positivity was associated with short survival, which is consistent with previous data.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5792
pubmed:author
pubmed:copyrightInfo
Copyright 2002 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-42
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Hepatic failure due to CD3+ plasma cell infiltration of the liver in multiple myeloma.
pubmed:affiliation
Department of Haematology, Gazi Medical School, Gazi University, TR-06610 Ankara, Turkey. erhem@med.gazi.edu.tr
pubmed:publicationType
Journal Article, Case Reports