Linked Life Data

11816820

Source:http://linkedlifedata.com/resource/pubmed/id/11816820

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-12-5
pubmed:abstractText
The readily available technique of screening for gene polymorphisms could be used to explain inter-individual variability in a classic occupational interstitial lung disease, such as coal workers' pneumoconiosis (CWP). The objective of this paper is to describe candidate genes selected from the wide pool of cytokines and growth factors, and to discuss the applications and pitfalls when using them as biomarkers for susceptibility to CWP. The selection of candidate genes is mainly based on observed phenotypic changes in bronchoalveolar lavage (BAL) fluid or BAL cells of patients with CWP, or on animal experiments that use quartz as the fibrogenic agent. This paper also reviews the studies that have been performed to validate tumour necrosis factor genotype and phenotype with respect to CWP. Finally, it is proposed that a multiple marker approach to susceptibility to CWP should be used. This involves the measurement of two cytokines (tumour necrosis factor and transforming growth factor-beta) to improve denomination of high- and low-risk groups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0904-1850
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127s-133s
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Genotype and phenotype in susceptibility to coal workers' pneumoconiosis. the use of cytokines in perspective.
pubmed:affiliation
Dept of Fiber and Particle Toxicology, Medical Institute for Environmental Hygiene, University of Dusseldorf, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't