Linked Life Data

11809694

Source:http://linkedlifedata.com/resource/pubmed/id/11809694

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-1-25
pubmed:abstractText
Laparoscopic colectomy for curable colon cancer may result in the development of abdominal wall implants because of disseminated disease and the favorable environment of the wound site for cell implantation. Injection of disaggregated human GW39 colon cancer cells into the hamster peritoneum represents a model of tumor spillage that may occur during dissection, manipulation, resection, and extraction of tumor during surgery in the clinical setting. Using this well-established animal model, we tested the efficacy of (64)Cu-pyruvaldehyde-bis(N(4)-methylthiosemicarbazone) ((64)Cu-PTSM) in inhibiting tumor cell implantation in trocar wound sites. Anesthetized hamsters had four 5-mm trocars inserted through the anterior abdominal wall. GW39 cells ( approximately 3.2 x 10(4) cells in 0.5 ml) were injected into the peritoneum through a midline incision. Ten min later, hamsters were randomized to receive 5, 3, or 1 mCi of (64)Cu-PTSM through the same midline incision. High-resolution magnetic resonance imaging and microPET were used to monitor tumor volume and morphology after surgery. After 7 weeks, animals were sacrificed, and trocar and midline wounds were harvested for macroscopic and histological analysis. No macroscopic tumor was found in any of the group treated with 5 mCi of (64)Cu-PTSM, whereas 96% of the wound sites in the group treated with saline had macroscopic tumor growth (P < 0.001). This study demonstrates the therapeutic potential of (64)Cu-PTSM in inhibiting cancer cell implantation and growth at doses well below the maximum tolerated dose, with no signs of toxicity to the hamsters.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
445-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11809694-Abdominal Muscles, pubmed-meshheading:11809694-Abdominal Neoplasms, pubmed-meshheading:11809694-Animals, pubmed-meshheading:11809694-Cell Division, pubmed-meshheading:11809694-Colonic Neoplasms, pubmed-meshheading:11809694-Copper Radioisotopes, pubmed-meshheading:11809694-Cricetinae, pubmed-meshheading:11809694-Laparoscopy, pubmed-meshheading:11809694-Magnetic Resonance Imaging, pubmed-meshheading:11809694-Mesocricetus, pubmed-meshheading:11809694-Neoplasm Seeding, pubmed-meshheading:11809694-Organometallic Compounds, pubmed-meshheading:11809694-Radiopharmaceuticals, pubmed-meshheading:11809694-Thiosemicarbazones, pubmed-meshheading:11809694-Tissue Distribution, pubmed-meshheading:11809694-Tomography, Emission-Computed, pubmed-meshheading:11809694-Xenograft Model Antitumor Assays
pubmed:year
2002
pubmed:articleTitle
Copper-64-pyruvaldehyde-bis(N(4)-methylthiosemicarbazone) for the prevention of tumor growth at wound sites following laparoscopic surgery: monitoring therapy response with microPET and magnetic resonance imaging.
pubmed:affiliation
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.