| pubmed-article:11807393 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0021308 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0027021 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0449468 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:11807393 | lifeskim:mentions | umls-concept:C0047645 | lld:lifeskim |
| pubmed-article:11807393 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11807393 | pubmed:dateCreated | 2002-1-24 | lld:pubmed |
| pubmed-article:11807393 | pubmed:abstractText | Peroxynitrite is responsible for nitration in vivo, whereas myeloperoxidase can also catalyze protein nitration in the presence of high NO2(-) levels. Recent reports of myeloperoxidase-mediated enzyme inactivation or lipid peroxidation have suggested a role of myeloperoxidase in various pathological conditions. To clarify the role of myeloperoxidase in ischemic brain injury, the authors measured nitrotyrosine formation and infarct volume in myeloperoxidase-deficient or wild-type mice subjected to 2-hour focal cerebral ischemia-reperfusion. Twenty-four hours after reperfusion, infarct volume was significantly larger in myeloperoxidase-deficient mice than in wild-type mice (81 +/- 20 mm(3) vs. 52 +/- 13 mm(3), P < 0.01), and nitrotyrosine levels in the infarct region were higher in myeloperoxidase-deficient mice than in wild-type mice (13.4 +/- 6.1 microg/mg vs. 9.8 +/- 4.4 microg/mg, P = 0.13). Fourteen hours after reperfusion, the nitrotyrosine level was significantly higher in myeloperoxidase-deficient mice than in wild-type mice (3.3 +/- 2.9 microg/mg vs. 1.4 +/- 0.4 microg/mg, P < 0.05). The authors conclude that the absence of myeloperoxidase increases ischemic neuronal damage in vivo, and that the myeloperoxidase-mediated pathway is not responsible for the nitration reaction in cerebral ischemia-reperfusion. | lld:pubmed |
| pubmed-article:11807393 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11807393 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11807393 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11807393 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11807393 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11807393 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11807393 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11807393 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11807393 | pubmed:issn | 0271-678X | lld:pubmed |
| pubmed-article:11807393 | pubmed:author | pubmed-author:MaedaNobuyoN | lld:pubmed |
| pubmed-article:11807393 | pubmed:author | pubmed-author:TakizawaShuny... | lld:pubmed |
| pubmed-article:11807393 | pubmed:author | pubmed-author:ArataniYasuak... | lld:pubmed |
| pubmed-article:11807393 | pubmed:author | pubmed-author:FukuyamaNaoto... | lld:pubmed |
| pubmed-article:11807393 | pubmed:author | pubmed-author:HirabayashiHi... | lld:pubmed |
| pubmed-article:11807393 | pubmed:author | pubmed-author:KoyamaHidekiH | lld:pubmed |
| pubmed-article:11807393 | pubmed:author | pubmed-author:ShinoharaYuki... | lld:pubmed |
| pubmed-article:11807393 | pubmed:author | pubmed-author:NakazawaHiroe... | lld:pubmed |
| pubmed-article:11807393 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11807393 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:11807393 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11807393 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11807393 | pubmed:pagination | 50-4 | lld:pubmed |
| pubmed-article:11807393 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11807393 | pubmed:meshHeading | pubmed-meshheading:11807393... | lld:pubmed |
| pubmed-article:11807393 | pubmed:meshHeading | pubmed-meshheading:11807393... | lld:pubmed |
| pubmed-article:11807393 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11807393 | pubmed:articleTitle | Deficiency of myeloperoxidase increases infarct volume and nitrotyrosine formation in mouse brain. | lld:pubmed |
| pubmed-article:11807393 | pubmed:affiliation | Department of Neurology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. | lld:pubmed |
| pubmed-article:11807393 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11807393 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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