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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-1-23
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pubmed:abstractText |
Natural killer (NK) cells and interferon (IFN)-gamma have been implicated in immune surveillance against tumor development. Here we show that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell-mediated and IFN-gamma-dependent tumor surveillance. Administration of neutralizing monoclonal antibody against TRAIL promoted tumor development in mice subcutaneously inoculated with a chemical carcinogen methylcholanthrene (MCA). This protective effect of TRAIL was at least partly mediated by NK cells and totally dependent on IFN-gamma. In the absence of TRAIL, NK cells, or IFN-gamma, TRAIL-sensitive sarcomas preferentially emerged in MCA-inoculated mice. Moreover, development of spontaneous tumors in p53(+/-) mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10209050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10229107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10233883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10383128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10411544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10438925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10523613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10684858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10748228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-10974040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-11133760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-11135622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-11145715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-11257133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-11276199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-11282985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-11323675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-2683611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-3951539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-7540647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-7579198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-7637809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-7895156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-7922305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-8663110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-8777713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-8920866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9060447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9087414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9143706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9217161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9326928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9382834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9563466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9636188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9643560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9721089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9743343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11805143-9930862
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11805143-Animals,
pubmed-meshheading:11805143-Antibodies, Monoclonal,
pubmed-meshheading:11805143-Apoptosis,
pubmed-meshheading:11805143-Apoptosis Regulatory Proteins,
pubmed-meshheading:11805143-Cytotoxicity, Immunologic,
pubmed-meshheading:11805143-Interferon-gamma,
pubmed-meshheading:11805143-Killer Cells, Natural,
pubmed-meshheading:11805143-Male,
pubmed-meshheading:11805143-Membrane Glycoproteins,
pubmed-meshheading:11805143-Mice,
pubmed-meshheading:11805143-Mice, Inbred C57BL,
pubmed-meshheading:11805143-Mice, Knockout,
pubmed-meshheading:11805143-Neoplasms, Experimental,
pubmed-meshheading:11805143-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:11805143-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11805143-Tumor Suppressor Protein p53
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pubmed:year |
2002
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pubmed:articleTitle |
Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development.
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pubmed:affiliation |
Department of Immunology, Juntendo University, School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan. ktakeda@med.juntendo.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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