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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-1-17
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pubmed:abstractText |
Inflammatory reaction and intimal proliferation of smooth muscle cells are characteristics of vascular stenotic lesions. Nuclear factor kappaB (NF-kappaB) is involved in regulation of inflammation and cell survival in a variety of cell types. We tested a hypothesis that selective inhibition of NF-kappaB by expression of a mutated, nondegradable inhibitor of NF-kappaB, IkappaB-alphaM, would inhibit proinflammatory cytokine expression and proliferation in human vascular smooth muscle cell.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:copyrightInfo |
(c)2001 Elsevier Science.
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pubmed:issnType |
Print
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
198-206
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11796019-Adenoviridae,
pubmed-meshheading:11796019-Apoptosis,
pubmed-meshheading:11796019-Cell Count,
pubmed-meshheading:11796019-Cell Division,
pubmed-meshheading:11796019-Cell Nucleus,
pubmed-meshheading:11796019-Cell Survival,
pubmed-meshheading:11796019-Cells, Cultured,
pubmed-meshheading:11796019-Cytokines,
pubmed-meshheading:11796019-DNA-Binding Proteins,
pubmed-meshheading:11796019-Gene Expression Regulation, Viral,
pubmed-meshheading:11796019-Genetic Vectors,
pubmed-meshheading:11796019-Humans,
pubmed-meshheading:11796019-I-kappa B Proteins,
pubmed-meshheading:11796019-Interleukin-6,
pubmed-meshheading:11796019-Interleukin-8,
pubmed-meshheading:11796019-Lipopolysaccharides,
pubmed-meshheading:11796019-Mammary Arteries,
pubmed-meshheading:11796019-Muscle, Smooth, Vascular,
pubmed-meshheading:11796019-NF-kappa B,
pubmed-meshheading:11796019-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
An IkappaB-alpha mutant inhibits cytokine gene expression and proliferation in human vascular smooth muscle cells.
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pubmed:affiliation |
Division of Basic Medical Science, Mercer University School of Medicine and Medical Center of Central Georgia, Macon, Georgia 31207, USA. wang_z@mercer.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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