Linked Life Data

11793349

Source:http://linkedlifedata.com/resource/pubmed/id/11793349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-1-16
pubmed:abstractText
The distribution of the calcium-binding proteins calbindin-D28K (CB), parvalbumin (PV) and calretinin (CR), and of the nonphosphorylated neurofilament protein (with SMI-32) was investigated in the human basal ganglia to identify anatomofunctional territories. In the striatum, gradients of neuropil immunostaining define four major territories: The first (T1) includes all but the rostroventral half of the putamen and is characterized by enhanced matriceal PV and SMI-32 immunoreactivity (-ir). The second territory (T2) encompasses most part of the caudate nucleus (Cd) and rostral putamen (PuT), which show enhanced matriceal CB-ir. The third and fourth territories (T3 and T4) comprise rostroventral parts of Cd and PuT characterized by complementary patch/matrix distributions of CB- and CR-ir, and the accumbens nucleus (Acb), respectively. The latter is separated into lateral (prominently enhanced in CB-ir) and medial (prominently enhanced in CR-ir) subdivisions. In the pallidum, parallel gradients also delimit four territories, T1 in the caudal half of external (GPe) and internal (GPi) divisions, characterized by enhanced PV- and SMI-32-ir; T2 in their rostral half, characterized by enhanced CB-ir; and T3 and T4 in their rostroventral pole and in the subpallidal area, respectively, both expressing CB- and CR-ir but with different intensities. The subthalamic nucleus (STh) shows contrasting patterns of dense PV-ir (sparing only the most medial part) and low CB-ir. Expression of CR-ir is relatively low, except in the medial, low PV-ir, part of the nucleus, whereas SMI-32-ir is moderate across the whole nucleus. The substantia nigra is characterized by complementary patterns of high neuropil CB- and SMI-32-ir in pars reticulata (SNr) and high CR-ir in pars compacta (SNc) and in the ventral tegmental area (VTA). The compartmentalization of calcium-binding proteins and SMI-32 in the human basal ganglia, in particular in the striatum and pallidum, delimits anatomofunctional territories that are of significance for functional imaging studies and target selection in stereotactic neurosurgery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
443
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
86-103
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11793349-Aged, pubmed-meshheading:11793349-Antibodies, Monoclonal, pubmed-meshheading:11793349-Basal Ganglia, pubmed-meshheading:11793349-Calcium-Binding Protein, Vitamin D-Dependent, pubmed-meshheading:11793349-Calcium-Binding Proteins, pubmed-meshheading:11793349-Female, pubmed-meshheading:11793349-Globus Pallidus, pubmed-meshheading:11793349-Humans, pubmed-meshheading:11793349-Immunohistochemistry, pubmed-meshheading:11793349-Male, pubmed-meshheading:11793349-Middle Aged, pubmed-meshheading:11793349-Neostriatum, pubmed-meshheading:11793349-Neurofilament Proteins, pubmed-meshheading:11793349-Neurons, pubmed-meshheading:11793349-Parvalbumins, pubmed-meshheading:11793349-Phosphorylation, pubmed-meshheading:11793349-Substantia Nigra, pubmed-meshheading:11793349-Subthalamic Nucleus
pubmed:year
2002
pubmed:articleTitle
Neurochemical organization of the human basal ganglia: anatomofunctional territories defined by the distributions of calcium-binding proteins and SMI-32.
pubmed:affiliation
Laboratory for Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, Zurich, Switzerland. amorel@nch.unizh.ch
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't