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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-16
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pubmed:abstractText |
Anti-Galalpha 1-3Gal (Gal) antibodies (Ab) play a key role in the rejection of pig cells or organs transplanted into primates. A course of extracorporeal immunoadsorption (EIA) of anti-Gal Ab using an immunoaffinity column of a Gal type 6 oligosaccharide depletes Ab successfully, but Ab returns during the next few days. Although therapy with an anti-CD154 monoclonal antibody (mAb) prevents an induced Ab response to Gal or non-Gal epitopes, T cell-independent natural anti-Gal IgM and IgG return to baseline (pretransplant) levels. We have investigated the capacity of continuous i.v. infusion of bovine serum albumin conjugated to Gal type 6 oligosaccharide (BSA-Gal) to deplete or maintain depletion of circulating anti-Gal Ab.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-39
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:11792992-Animals,
pubmed-meshheading:11792992-Antibodies, Monoclonal,
pubmed-meshheading:11792992-Antibody Formation,
pubmed-meshheading:11792992-CD40 Ligand,
pubmed-meshheading:11792992-Carbohydrate Sequence,
pubmed-meshheading:11792992-Disaccharides,
pubmed-meshheading:11792992-Galactose,
pubmed-meshheading:11792992-Graft Rejection,
pubmed-meshheading:11792992-Graft Survival,
pubmed-meshheading:11792992-Hematopoietic Cell Growth Factors,
pubmed-meshheading:11792992-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:11792992-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11792992-Immunosorbent Techniques,
pubmed-meshheading:11792992-Immunosuppression,
pubmed-meshheading:11792992-Infusions, Intravenous,
pubmed-meshheading:11792992-Molecular Sequence Data,
pubmed-meshheading:11792992-Oligosaccharides,
pubmed-meshheading:11792992-Papio,
pubmed-meshheading:11792992-Primates,
pubmed-meshheading:11792992-Serum Albumin, Bovine,
pubmed-meshheading:11792992-Swine,
pubmed-meshheading:11792992-Swine, Miniature,
pubmed-meshheading:11792992-Time Factors,
pubmed-meshheading:11792992-Transplantation, Heterologous,
pubmed-meshheading:11792992-Whole-Body Irradiation
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pubmed:year |
2002
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pubmed:articleTitle |
Depletion of anti-gal antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides.
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pubmed:affiliation |
Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149-9019, 13th Street, Boston, MA 02129, USA.
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pubmed:publicationType |
Journal Article
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