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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
3
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pubmed:dateCreated |
2002-1-10
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|
pubmed:abstractText |
Conservatism of primary and secondary structure of osteopontin mRNA in vertebrates of various taxes was studied using computer analysis and blot-hybridization procedure. Relatively high rate of evolution of a nucleotide sequence of osteopontin gene was revealed. Formation of hairpin-loop structures by adjacent sequences and a high content of AU-pairs indicate more flexible structure of the mammalian osteopontin mRNA as compared with the avian one. It has been detected some AU-enriched regions in 3'-terminal untranslated sequences, which presence is characteristic for short-lived mRNA. Evolutionary conserved subsequences in 3'- and 5'-terminal regions were suggested to be determinants of RNA-protein interaction in cytoplasm.
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pubmed:language |
rus
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0564-3783
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-42
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pubmed:dateRevised |
2008-2-15
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pubmed:meshHeading |
pubmed-meshheading:11785431-3' Untranslated Regions,
pubmed-meshheading:11785431-5' Untranslated Regions,
pubmed-meshheading:11785431-Amino Acid Sequence,
pubmed-meshheading:11785431-Animals,
pubmed-meshheading:11785431-Base Sequence,
pubmed-meshheading:11785431-Birds,
pubmed-meshheading:11785431-Conserved Sequence,
pubmed-meshheading:11785431-Evolution, Molecular,
pubmed-meshheading:11785431-Immunoblotting,
pubmed-meshheading:11785431-Mammals,
pubmed-meshheading:11785431-Mathematical Computing,
pubmed-meshheading:11785431-Molecular Sequence Data,
pubmed-meshheading:11785431-Nucleic Acid Conformation,
pubmed-meshheading:11785431-Osteopontin,
pubmed-meshheading:11785431-Protein Structure, Secondary,
pubmed-meshheading:11785431-RNA, Messenger,
pubmed-meshheading:11785431-Sialoglycoproteins
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pubmed:articleTitle |
[Structural characteristics of osteopontin mRNA].
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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