Source:http://linkedlifedata.com/resource/pubmed/id/11784788
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-1-10
|
| pubmed:abstractText |
The lateral walls of the forebrain lateral ventricles are the richest source of stem cells in the adult mammalian brain. These stem cells give rise to new olfactory neurons that are renewed throughout life. The neurons originate in the subventricular zone (SVZ), migrate within the rostral extension (RE) of the SVZ along the rostral migratory stream (RMS) within tube-like structures formed of glial cells, to eventually reach the olfactory bulb (OB). We demonstrate that, contrary to the current view, multipotential (neuronal-astroglial-oligodendroglial) precursors with stem cell features can be isolated not only from the SVZ but also from the entire RE, including the distal portion within the OB. Specifically, these stem cells do not derive from the migratory neuroblasts coming from the SVZ. Interestingly, stem cells isolated from the proximal RE generate significantly more oligodendrocytes, and those from the distal RE proliferate significantly more slowly than stem cells derived from the SVZ and other RE regions. These findings demonstrate that stem cells are not confined to the forebrain periventricular region and indicate that stem cells endowed with different functional characteristics occur at different levels of the SVZ-RE pathway.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1529-2401
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| pubmed:author |
pubmed-author:Alvarez-BuyllaArturoA,
pubmed-author:BonfantiLucaL,
pubmed-author:CailleIsabelleI,
pubmed-author:DoetschFionaF,
pubmed-author:GalliRossellaR,
pubmed-author:GrittiAngelaA,
pubmed-author:HerreraDaniel GDG,
pubmed-author:LimDaniel ADA,
pubmed-author:VerdugoJose Manuel GarciaJM,
pubmed-author:VescoviAngelo LAL
|
| pubmed:issnType |
Electronic
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| pubmed:day |
15
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
437-45
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11784788-Animals,
pubmed-meshheading:11784788-Astrocytes,
pubmed-meshheading:11784788-Cell Culture Techniques,
pubmed-meshheading:11784788-Cell Differentiation,
pubmed-meshheading:11784788-Cell Division,
pubmed-meshheading:11784788-Cell Line,
pubmed-meshheading:11784788-Cell Movement,
pubmed-meshheading:11784788-Cell Separation,
pubmed-meshheading:11784788-Cells, Cultured,
pubmed-meshheading:11784788-Clone Cells,
pubmed-meshheading:11784788-Growth Substances,
pubmed-meshheading:11784788-Lateral Ventricles,
pubmed-meshheading:11784788-Mice,
pubmed-meshheading:11784788-Neurons,
pubmed-meshheading:11784788-Neurotransmitter Agents,
pubmed-meshheading:11784788-Olfactory Bulb,
pubmed-meshheading:11784788-Oligodendroglia,
pubmed-meshheading:11784788-Phenotype,
pubmed-meshheading:11784788-Spheroids, Cellular,
pubmed-meshheading:11784788-Stem Cells,
pubmed-meshheading:11784788-Time Factors
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents.
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| pubmed:affiliation |
Institute for Stem Cell Research, Department of Biotechnology, San Raffaele Hospital, 20132 Milan, Italy. gritti.angela@hsr.it.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|