rdf:type |
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lifeskim:mentions |
umls-concept:C0003847,
umls-concept:C0009813,
umls-concept:C0020538,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0443199,
umls-concept:C0443211,
umls-concept:C0915167,
umls-concept:C1261287,
umls-concept:C1280500,
umls-concept:C1760025,
umls-concept:C2684089
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pubmed:issue |
6
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pubmed:dateCreated |
2002-1-8
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pubmed:abstractText |
To determine whether two structurally and mechanistically different inhibitors of cytochrome P-450 omega-hydroxylase would alter the enhanced vasoconstrictor response to elevated PO2 in arterioles of spontaneously hypertensive rats (SHR). Cytochrome P-450 omega-hydroxylases, which catalyze the formation of the vasoconstrictor 20-hydroxyeicosatetraenoic acid from arachidonic acid, have been proposed to serve as microvascular O2 sensors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/17-octadecynoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/DDMS,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyeicosatetraenoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/cytochrome P-450 omega-hydroxylase
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1073-9688
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
435-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11781816-Amides,
pubmed-meshheading:11781816-Animals,
pubmed-meshheading:11781816-Arterioles,
pubmed-meshheading:11781816-Cytochrome P-450 Enzyme System,
pubmed-meshheading:11781816-Dose-Response Relationship, Drug,
pubmed-meshheading:11781816-Enzyme Inhibitors,
pubmed-meshheading:11781816-Fatty Acids, Unsaturated,
pubmed-meshheading:11781816-Hydroxyeicosatetraenoic Acids,
pubmed-meshheading:11781816-Hypertension,
pubmed-meshheading:11781816-Mixed Function Oxygenases,
pubmed-meshheading:11781816-Oxygen,
pubmed-meshheading:11781816-Rats,
pubmed-meshheading:11781816-Rats, Inbred SHR,
pubmed-meshheading:11781816-Sulfones,
pubmed-meshheading:11781816-Vasoconstriction
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pubmed:year |
2001
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pubmed:articleTitle |
Differential effect of cytochrome P-450 omega-hydroxylase inhibition on O2-induced constriction of arterioles in SHR with early and established hypertension.
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pubmed:affiliation |
Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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