Source:http://linkedlifedata.com/resource/pubmed/id/11781381
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2002-1-8
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pubmed:abstractText |
Apoptosis of neurons and astrocytes has been found in patients undergoing AIDS dementia complex. We demonstrated that supernatants from human primary macrophages (M/M) infected by HIV-1 lead human astroglial cells to oxidative stress, as shown by elevated levels of malondialdehyde, and then to apoptosis. Electron microscopy of astrocytes shortly incubated with HIV-1-infected M/M supernatants showed apoptotic blebbing, cytoplasmic loss, and chromatin condensation. Apoptosis was antagonized by pretreating astrocytes with the nonpeptidic superoxide dismutase (SOD) mimetic M40401 but not with anti-HIV-1 compounds, thus showing that apoptosis of astrocytes driven by HIV-1-infected M/M supernatants is mainly mediated by abnormal production of superoxide anions without relationship to HIV-1 replication in such cells. Overall results support the role of oxidative stress mediated by HIV-1-infected M/M as one of the leading causes of neurodegeneration in patients with HIV-1 and suggest the use of nonpeptidic SOD mimetics to counteract HIV-1-related neurological disorders.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0741-5400
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pubmed:author |
pubmed-author:AquaroStefanoS,
pubmed-author:BerrierJJ,
pubmed-author:GranatoTeresaT,
pubmed-author:IannoneMichelangeloM,
pubmed-author:MasuelliLauraL,
pubmed-author:ModestiAndreaA,
pubmed-author:MollaceVincenzoV,
pubmed-author:MuscoliCarolinaC,
pubmed-author:NisticóRobertR,
pubmed-author:PernoCarlo-FedericoCF,
pubmed-author:RileyDennis PDP,
pubmed-author:RotirotiDomenicantonioD,
pubmed-author:SalveminiDanielaD
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11781381-Apoptosis,
pubmed-meshheading:11781381-Astrocytes,
pubmed-meshheading:11781381-Cells, Cultured,
pubmed-meshheading:11781381-Culture Media, Conditioned,
pubmed-meshheading:11781381-HIV Infections,
pubmed-meshheading:11781381-HIV-1,
pubmed-meshheading:11781381-Humans,
pubmed-meshheading:11781381-Macrophages,
pubmed-meshheading:11781381-Oxidative Stress
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pubmed:year |
2002
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pubmed:articleTitle |
The contribution of oxidative stress in apoptosis of human-cultured astroglial cells induced by supernatants of HIV-1-infected macrophages.
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pubmed:affiliation |
Faculty of Pharmacy, University of Catanzaro Magna Graecia, Roccelletta di Borgia, Italy. mollace@libero.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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