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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-7
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pubmed:abstractText |
Phosphorylation of p53 at Ser 46 was shown to regulate p53 apoptotic activity. Here we demonstrate that homeodomain-interacting protein kinase-2 (HIPK2), a member of a novel family of nuclear serine/threonine kinases, binds to and activates p53 by directly phosphorylating it at Ser 46. HIPK2 localizes with p53 and PML-3 into the nuclear bodies and is activated after irradiation with ultraviolet. Antisense inhibition of HIPK2 expression reduces the ultraviolet-induced apoptosis. Furthermore, HIPK2 and p53 cooperate in the activation of p53-dependent transcription and apoptotic pathways. These data define a new functional interaction between p53 and HIPK2 that results in the targeted subcellular localization of p53 and initiation of apoptosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HIPK2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hipk2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/PML protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pml protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1465-7392
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pubmed:author |
pubmed-author:AppellaEttoreE,
pubmed-author:BrunoTizianaT,
pubmed-author:CecchinelliBarbaraB,
pubmed-author:CoenSabrinaS,
pubmed-author:D'OraziGabriellaG,
pubmed-author:Del SalGianninoG,
pubmed-author:FanciulliMaurizioM,
pubmed-author:GostissaMonicaM,
pubmed-author:HigashimotoYuichiroY,
pubmed-author:ManniIsabellaI,
pubmed-author:MarchettiAlessandraA,
pubmed-author:PiaggioGuiliaG,
pubmed-author:SaitoShin'ichiS,
pubmed-author:SodduSilviaS
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11780126-Animals,
pubmed-meshheading:11780126-Apoptosis,
pubmed-meshheading:11780126-Carrier Proteins,
pubmed-meshheading:11780126-Cell Nucleus,
pubmed-meshheading:11780126-Enzyme Activation,
pubmed-meshheading:11780126-Genes, Tumor Suppressor,
pubmed-meshheading:11780126-Humans,
pubmed-meshheading:11780126-Mice,
pubmed-meshheading:11780126-Neoplasm Proteins,
pubmed-meshheading:11780126-Nuclear Proteins,
pubmed-meshheading:11780126-Oligonucleotides, Antisense,
pubmed-meshheading:11780126-Phosphorylation,
pubmed-meshheading:11780126-Protein Isoforms,
pubmed-meshheading:11780126-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11780126-Serine,
pubmed-meshheading:11780126-Transcription Factors,
pubmed-meshheading:11780126-Transcriptional Activation,
pubmed-meshheading:11780126-Tumor Cells, Cultured,
pubmed-meshheading:11780126-Tumor Suppressor Protein p53,
pubmed-meshheading:11780126-Tumor Suppressor Proteins,
pubmed-meshheading:11780126-Ultraviolet Rays
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pubmed:year |
2002
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pubmed:articleTitle |
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
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pubmed:affiliation |
Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d Oro 156, 00158 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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