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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6867
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pubmed:dateCreated |
2002-1-7
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pubmed:abstractText |
The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than inactivated p53. Mutant (p53+/m) mice exhibit enhanced resistance to spontaneous tumours compared with wild-type (p53+/+) littermates. As p53+/m mice age, they display an early onset of phenotypes associated with ageing. These include reduced longevity, osteoporosis, generalized organ atrophy and a diminished stress tolerance. A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0028-0836
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pubmed:author |
pubmed-author:BradleyAllanA,
pubmed-author:BraytonCoryC,
pubmed-author:ChoiJeneJ,
pubmed-author:CooperBenjaminB,
pubmed-author:DonehowerLawrence ALA,
pubmed-author:GhebraniousNaderN,
pubmed-author:Hee ParkSangS,
pubmed-author:IgelmannHerbertH,
pubmed-author:JonesStephenS,
pubmed-author:KarsentyGerardG,
pubmed-author:LuXiongbinX,
pubmed-author:SoronGabrielleG,
pubmed-author:ThompsonTimothyT,
pubmed-author:TynerStuart DSD,
pubmed-author:VenkatachalamSundaresanS
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
415
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11780111-Adipose Tissue,
pubmed-meshheading:11780111-Aging,
pubmed-meshheading:11780111-Aging, Premature,
pubmed-meshheading:11780111-Alleles,
pubmed-meshheading:11780111-Animals,
pubmed-meshheading:11780111-Body Weight,
pubmed-meshheading:11780111-Bone and Bones,
pubmed-meshheading:11780111-Cell Transformation, Neoplastic,
pubmed-meshheading:11780111-Cells, Cultured,
pubmed-meshheading:11780111-Exons,
pubmed-meshheading:11780111-Female,
pubmed-meshheading:11780111-Genes, p53,
pubmed-meshheading:11780111-Hair,
pubmed-meshheading:11780111-Longevity,
pubmed-meshheading:11780111-Male,
pubmed-meshheading:11780111-Mice,
pubmed-meshheading:11780111-Mice, Transgenic,
pubmed-meshheading:11780111-Neoplasms,
pubmed-meshheading:11780111-Organ Size,
pubmed-meshheading:11780111-Osteoporosis,
pubmed-meshheading:11780111-Phenotype,
pubmed-meshheading:11780111-RNA, Messenger,
pubmed-meshheading:11780111-Sequence Deletion,
pubmed-meshheading:11780111-Skin,
pubmed-meshheading:11780111-Tumor Suppressor Protein p53,
pubmed-meshheading:11780111-Wound Healing
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pubmed:year |
2002
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pubmed:articleTitle |
p53 mutant mice that display early ageing-associated phenotypes.
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pubmed:affiliation |
Cell and Molecular Biology Program, Baylor College of Medicine, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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