Source:http://linkedlifedata.com/resource/pubmed/id/11779726
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2002-1-7
|
| pubmed:abstractText |
Inhalation of heparin attenuates hyperventilation-induced bronchoconstriction in humans and dogs. The purpose of this study was to determine whether heparin inhibits the late-phase response to hyperventilation, which is characterized by increased peripheral airway resistance (RP), eicosanoid mediator production, neutrophilic/ eosinophilic inflammation, and airway hyperreactivity (AHR) at 5 h after dry air challenge (DAC). Fiberoptic bronchoscopy was used to record RP and airway reactivity (DeltaRP) to aerosol and intravenous histamine before and 5 h after DAC. Bronchoalveolar lavage fluid (BALF) cells and eicosanoid mediators were also measured approximately 5 h after DAC. DAC of vehicle-treated bronchi resulted in late-phase airway obstruction (approximately 120% increase over baseline RP), inflammation, increased BALF concentrations of leukotriene (LT) C(4), LTD(4), and LTE(4) and prostaglandin (PG)D(2), and AHR. Pretreatment with aerosolized heparin attenuated late-phase airway obstruction by approximately 50%, inhibited eosinophil infiltration, reduced BALF concentrations of LTC(4), LTD(4), and LTE(4) and PGD(2), and abolished AHR. We conclude that heparin inhibits hyperventilation-induced late-phase changes in peripheral airway function, and does so in part via the inhibition of eosinophil migration and eicosanoid mediator production and release.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Eicosanoids,
http://linkedlifedata.com/resource/pubmed/chemical/Heparin,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene C4,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene D4,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene E4,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
165
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
27-33
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:11779726-Administration, Inhalation,
pubmed-meshheading:11779726-Airway Resistance,
pubmed-meshheading:11779726-Animals,
pubmed-meshheading:11779726-Bronchial Hyperreactivity,
pubmed-meshheading:11779726-Bronchial Provocation Tests,
pubmed-meshheading:11779726-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:11779726-Bronchoscopy,
pubmed-meshheading:11779726-Disease Models, Animal,
pubmed-meshheading:11779726-Dogs,
pubmed-meshheading:11779726-Drug Evaluation, Preclinical,
pubmed-meshheading:11779726-Eicosanoids,
pubmed-meshheading:11779726-Eosinophils,
pubmed-meshheading:11779726-Heparin,
pubmed-meshheading:11779726-Humans,
pubmed-meshheading:11779726-Hyperventilation,
pubmed-meshheading:11779726-Inflammation,
pubmed-meshheading:11779726-Leukotriene C4,
pubmed-meshheading:11779726-Leukotriene D4,
pubmed-meshheading:11779726-Leukotriene E4,
pubmed-meshheading:11779726-Male,
pubmed-meshheading:11779726-Neutrophils,
pubmed-meshheading:11779726-Prostaglandin D2,
pubmed-meshheading:11779726-Time Factors
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs.
|
| pubmed:affiliation |
Department of Environmental Health Sciences, The Johns Hopkins School of Public Health, Baltimore, Maryland 20892-7924, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|