Linked Life Data

11773817

Source:http://linkedlifedata.com/resource/pubmed/id/11773817

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-1-4
pubmed:abstractText
The purpose of this study was to investigate the effect of different concentrations of desflurane on jugular bulb gases and jugular bulb pressure (JBP) and to determine an optimal concentration of desflurane in neurosurgical patients with supratentorial tumor. Twenty-two patients were anesthetized with desflurane in oxygen. Radial arterial and jugular bulb catheters were inserted for blood gas sampling and direct blood pressure measurement after anesthesia. Mean arterial blood pressure (MAP), heart rate (HR), and JBP were monitored continuously. Arterial and jugular bulb blood gases were measured at 0.7 minimum alveolar contraction (MAC) (4.2%), 1.0 MAC (6%), and 1.3 MAC (7.8%) of desflurane randomly after a 30-minute stabilization period, respectively. Jugular bulb oxygen saturation (S(J)O2) significantly increased and cerebral arteriojugular difference of oxygen content (A(J)DO2) and oxygen extraction ratio (O2ER) significantly decreased from 0.7 MAC to 1.0 MAC of desflurane, but there was no further increase in S(J)O2 nor further decreases in A(J)DO2 and O2ER at 1.3 MAC compared with 1.0 MAC desflurane. There was a significant dose-related decrease in MAP from 0.7 MAC to 1.3 MAC of desflurane, but JBP did not change significantly. No significant change in hour was observed in the study. It is concluded that 1.0 MAC is a suitable concentration of desflurane in neurosurgery with an improved balance between cerebral oxygen supply and demand.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0898-4921
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Effects of desflurane on jugular bulb gases and pressure in neurosurgical patients.
pubmed:affiliation
Department of Anesthesiology, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, People's Republic of China.
pubmed:publicationType
Journal Article