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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-4
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pubmed:abstractText |
Coeliac disease is characterised by atrophy of the villi and hyperplasia of the crypts in the mucosa of the small intestine. It is caused by an environmental trigger, cereal gluten, which induces infiltration of the mucosa by inflammatory cells. We hypothesised that these inflammatory cells express cyclooxygenase 2 (COX-2), an enzyme that contributes to the synthesis of pro and anti-inflammatory prostaglandins and is known to be expressed at sites of inflammation in the stomach and colon. We have investigated expression of COX-2 in the coeliac disease affected small intestinal mucosa where it may be an indicator of either disease induction or mucosal restoration processes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10069362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10213117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10235197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10371510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10384106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10426313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10500058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10638762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-10696997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-1286027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-1901879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-2298918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-2439242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-2837956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-3106472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-3144716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-3680546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-4374474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-6967616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-7622185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-7738031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-8094672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-8144193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-8613040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-8643612,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-9679035,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-9929039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11772972-9933424
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11772972-Adolescent,
pubmed-meshheading:11772972-Adult,
pubmed-meshheading:11772972-Aged,
pubmed-meshheading:11772972-Antigens, CD3,
pubmed-meshheading:11772972-Antigens, CD45,
pubmed-meshheading:11772972-Blister,
pubmed-meshheading:11772972-Case-Control Studies,
pubmed-meshheading:11772972-Celiac Disease,
pubmed-meshheading:11772972-Cell Count,
pubmed-meshheading:11772972-Female,
pubmed-meshheading:11772972-Humans,
pubmed-meshheading:11772972-Image Processing, Computer-Assisted,
pubmed-meshheading:11772972-Intestinal Mucosa,
pubmed-meshheading:11772972-Male,
pubmed-meshheading:11772972-Microscopy, Immunoelectron,
pubmed-meshheading:11772972-Middle Aged,
pubmed-meshheading:11772972-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:11772972-T-Lymphocytes
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pubmed:year |
2002
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pubmed:articleTitle |
Blisters in the small intestinal mucosa of coeliac patients contain T cells positive for cyclooxygenase 2.
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pubmed:affiliation |
Institute of Medical Technology, University of Tampere, Tampere, Finland. heikka.kainulainen@uta.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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