|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2001-12-18
|
|
pubmed:abstractText |
Gravin is expressed in several cell and tissue types as either 300 kDa doublet or 250 kDa proteolytic products. It is a cytoplasmic antigen that reacts with the serum of patients with myasthenia gravis (MG). Autoantibodies to gravin residues 1477-1781 are highly specific for MG. In the present study, we examined residues 1477-1781 in detail and found that residues 1542-1547 of gravin protein, which had sequence homology with the binding sequences of two protein A-kinase anchoring proteins, were highly reactive to MG serum. Antigravin antibody activities were stronger in younger and nonthymomatous patients. These findings suggest that antigravin antibody activities could be a useful prognostic factor and that the gravin antibody of MG may have a function which prevents the protein A-kinase binding pathway.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0941-1291
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1036-7
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:11766078-A Kinase Anchor Proteins,
pubmed-meshheading:11766078-Adult,
pubmed-meshheading:11766078-Aged,
pubmed-meshheading:11766078-Autoantibodies,
pubmed-meshheading:11766078-Autoantigens,
pubmed-meshheading:11766078-Binding Sites, Antibody,
pubmed-meshheading:11766078-Cell Cycle Proteins,
pubmed-meshheading:11766078-Female,
pubmed-meshheading:11766078-Humans,
pubmed-meshheading:11766078-Male,
pubmed-meshheading:11766078-Middle Aged,
pubmed-meshheading:11766078-Myasthenia Gravis,
pubmed-meshheading:11766078-Proteins
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Autoantibody to gravin is expressed more strongly in younger and nonthymomatous patients with myasthenia gravis.
|
|
pubmed:affiliation |
Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan.
|
|
pubmed:publicationType |
Journal Article
|
