Linked Life Data

11759285

Source:http://linkedlifedata.com/resource/pubmed/id/11759285

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-12-10
pubmed:abstractText
Dietary supplements containing concentrates of plant-derived estrogens are being increasingly used by consumers as alternatives for hormone replacement therapy, for treatment of menopausal symptoms, and as cancer preventives. The effect of dietary genistein on dimethylbenz[a]anthracene (DMBA)-induced mammary tumor development was investigated in wild-type (ER alpha WT) and estrogen receptor-alpha knockout (ER alpha KO) mice. ER alpha WT and ER alpha KO mice were fed a casein-based diet containing 0 or 1 g genistein/kg diet from weaning. Tumors were induced by oral administration of DMBA and subscapular implantation of medroxyprogesterone acetate. No tumors were observed in ER alpha KO mice. In ER alpha WT mice, dietary intake of genistein influenced tumor development, enhancing anaplasia of mammary cancer. Mice consuming genistein expressed malignant mammary adenocarcinoma, whereas benign adenomas were observed in mice fed the control diet. Dietary intake was also influenced by genistein, with ER alpha WT and ER alpha KO mice fed genistein consuming less food (p < 0.0001) and subsequently weighing less than mice fed the control diet (p < 0.0001). Significant differences in food intake by genotype were also observed (p = 0.0017), with ER alpha KO mice consuming less than ER alpha WT mice. Overall, this study found no protective effect of genistein on DMBA-induced mammary tumors in mice and suggests a potential adverse effect on tumor development when high levels of genistein are consumed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0163-5581
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
226-32
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11759285-9,10-Dimethyl-1,2-benzanthracene, pubmed-meshheading:11759285-Adenocarcinoma, pubmed-meshheading:11759285-Animals, pubmed-meshheading:11759285-Caseins, pubmed-meshheading:11759285-Diet, pubmed-meshheading:11759285-Estradiol, pubmed-meshheading:11759285-Estrogen Receptor alpha, pubmed-meshheading:11759285-Female, pubmed-meshheading:11759285-Genistein, pubmed-meshheading:11759285-Insulin-Like Growth Factor I, pubmed-meshheading:11759285-Male, pubmed-meshheading:11759285-Mammary Neoplasms, Experimental, pubmed-meshheading:11759285-Medroxyprogesterone Acetate, pubmed-meshheading:11759285-Mice, pubmed-meshheading:11759285-Mice, Inbred C57BL, pubmed-meshheading:11759285-Mice, Knockout, pubmed-meshheading:11759285-Organ Size, pubmed-meshheading:11759285-Ovary, pubmed-meshheading:11759285-Receptors, Estrogen, pubmed-meshheading:11759285-Skin Neoplasms, pubmed-meshheading:11759285-Uterus, pubmed-meshheading:11759285-Weight Gain
pubmed:year
2001
pubmed:articleTitle
Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice.
pubmed:affiliation
Genetics Area Program, Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't