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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1975-12-20
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pubmed:abstractText |
Cats were made tolerant and physically dependent by twice daily equieffective anesthetic dosing with sodium pentobarbital intragastrically for 5 weeks. Serial blood and CSF samples were simultaneously collected on day 1 and day 35 and analyzed for pentobarbital by a gas chromatographic method. Pentobarbital penetration into CSF was rapid and unchanged by chronic treatment. The concentration in blood and CSF increased significantly with chronic treatment; however, the relative CSF/blood concentration ratios were unchanged.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
205-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1175687-Animals,
pubmed-meshheading:1175687-Cats,
pubmed-meshheading:1175687-Cerebellum,
pubmed-meshheading:1175687-Drug Tolerance,
pubmed-meshheading:1175687-Female,
pubmed-meshheading:1175687-Kinetics,
pubmed-meshheading:1175687-Male,
pubmed-meshheading:1175687-Medulla Oblongata,
pubmed-meshheading:1175687-Pentobarbital,
pubmed-meshheading:1175687-Time Factors
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pubmed:year |
1975
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pubmed:articleTitle |
Effect of chronic pentobarbital treatment on blood-cerebrospinal fluid kinetics.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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