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rdf:type |
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lifeskim:mentions |
umls-concept:C0296250,
umls-concept:C0443199,
umls-concept:C0542341,
umls-concept:C1155013,
umls-concept:C1334333,
umls-concept:C1514562,
umls-concept:C1514873,
umls-concept:C1705639,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
6
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pubmed:dateCreated |
2001-12-28
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pubmed:abstractText |
The hematopoietic cell-specific adaptor protein, SLP-76, is critical for T cell development and mature T cell receptor (TCR) signaling; however, the structural requirements of SLP-76 for mediating thymopoiesis and mature T cell function remain largely unknown. In this study, transgenic mice were generated to examine the requirements for specific domains of SLP-76 in thymocytes and peripheral T cells in vivo. Examination of mice expressing various mutants of SLP-76 on the null background demonstrates a differential requirement for specific domains of SLP-76 in thymocytes and T cells and provides new insight into the molecular mechanisms underlying SLP-76 function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lat protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SLP-76 signal Transducing adaptor...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1011-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11754821-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11754821-Amino Acid Motifs,
pubmed-meshheading:11754821-Amino Acid Substitution,
pubmed-meshheading:11754821-Animals,
pubmed-meshheading:11754821-Antigens, CD3,
pubmed-meshheading:11754821-Binding Sites,
pubmed-meshheading:11754821-Calcium Signaling,
pubmed-meshheading:11754821-Carrier Proteins,
pubmed-meshheading:11754821-Cell Differentiation,
pubmed-meshheading:11754821-Clonal Deletion,
pubmed-meshheading:11754821-Immunophenotyping,
pubmed-meshheading:11754821-Membrane Proteins,
pubmed-meshheading:11754821-Mice,
pubmed-meshheading:11754821-Mice, Inbred C57BL,
pubmed-meshheading:11754821-Mice, Knockout,
pubmed-meshheading:11754821-Mice, Transgenic,
pubmed-meshheading:11754821-Mutation, Missense,
pubmed-meshheading:11754821-Phosphoproteins,
pubmed-meshheading:11754821-Protein Structure, Tertiary,
pubmed-meshheading:11754821-Receptors, Antigen, T-Cell,
pubmed-meshheading:11754821-Recombinant Fusion Proteins,
pubmed-meshheading:11754821-Sequence Deletion,
pubmed-meshheading:11754821-Signal Transduction,
pubmed-meshheading:11754821-Spleen,
pubmed-meshheading:11754821-Structure-Activity Relationship,
pubmed-meshheading:11754821-T-Lymphocytes,
pubmed-meshheading:11754821-Thymus Gland,
pubmed-meshheading:11754821-src Homology Domains
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pubmed:year |
2001
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pubmed:articleTitle |
Differential requirement for SLP-76 domains in T cell development and function.
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pubmed:affiliation |
Graduate Program in Immunology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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