Source:http://linkedlifedata.com/resource/pubmed/id/11754004
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-12-25
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| pubmed:abstractText |
We recently reported the cloning of two triggering receptors expressed by myeloid cells (TREM), TREM-2a and TREM-2b, which are highly homologous to each other. These receptors associate with DAP12, and ligation of TREM-2 on the surface of macrophages leads to the release of nitric oxide. Using the immunoglobulin (Ig) domain of TREM-2 to screen a mouse EST database we have isolated a novel receptor, derived from a WEHI-3 macrophage library, which shows homology to TREM-2 (20%). The DNA sequence of this receptor has been submitted to Genbank with the name TREM-3. The predicted amino acid sequence contains a single Ig domain and a transmembrane lysine residue. We found transcripts for TREM-3 in two macrophage cell lines (RAW264.7 and MT2) but not in P388D1 macrophage cells. TREM-3 transcripts could also be detected at low levels in T cell lines, but were not detectable in NK, B cell, or mast cell lines. Furthermore, in macrophage cells, transcripts for TREM-3 were up-regulated by LPS, but were down-regulated by IFN-gamma. Like TREM-1 and TREM-2, TREM-3 signals through DAP12, and when TREM-3 is transfected into an NK cell line it mediates redirected lysis. Thus, TREM-3 functions as an activating receptor. Analysis of the mouse genome reveals that the gene for TREM-3 lies adjacent to the gene for TREM-1 and in close proximity to a number of other single Ig domain receptors, including TREM-2. Thus, TREM-3 is a novel member of a family of immunoglobulin receptors that form an innate immune gene complex on chromosome 17.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/TYROBP protein, human
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0014-2980
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
59-66
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11754004-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11754004-Amino Acid Sequence,
pubmed-meshheading:11754004-Animals,
pubmed-meshheading:11754004-Cell Line,
pubmed-meshheading:11754004-Chromosome Mapping,
pubmed-meshheading:11754004-Chromosomes,
pubmed-meshheading:11754004-Cross-Linking Reagents,
pubmed-meshheading:11754004-Gene Expression,
pubmed-meshheading:11754004-Immunoglobulins,
pubmed-meshheading:11754004-Lipopolysaccharides,
pubmed-meshheading:11754004-Macrophages,
pubmed-meshheading:11754004-Membrane Proteins,
pubmed-meshheading:11754004-Mice,
pubmed-meshheading:11754004-Molecular Sequence Data,
pubmed-meshheading:11754004-RNA, Messenger,
pubmed-meshheading:11754004-Receptors, Immunologic,
pubmed-meshheading:11754004-Sequence Homology, Amino Acid,
pubmed-meshheading:11754004-Up-Regulation
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| pubmed:year |
2002
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| pubmed:articleTitle |
Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17.
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| pubmed:affiliation |
Department of Immunology, VA Medical Center and University of California San Francisco, San Francisco, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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