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rdf:type |
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|
lifeskim:mentions |
umls-concept:C0002351,
umls-concept:C0024204,
umls-concept:C0025723,
umls-concept:C0026882,
umls-concept:C0027646,
umls-concept:C0030705,
umls-concept:C0069197,
umls-concept:C0178759,
umls-concept:C0242793,
umls-concept:C0332281,
umls-concept:C0699791,
umls-concept:C1269955,
umls-concept:C1708822,
umls-concept:C2699153
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|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2001-12-25
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|
pubmed:abstractText |
O(6)-methylguanine-DNA methyltransferase (MGMT) can remove O(6)alkylG DNA adducts. If they are not removed, then the adducts mispair with T during DNA replication, resulting in G-to-A mutation. Interrelations between MGMT gene inactivation by promoter methylation, K-ras mutation, and clinicopathologic features in patients with gastric carcinoma were studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2760-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11753949-Adenocarcinoma,
pubmed-meshheading:11753949-Adult,
pubmed-meshheading:11753949-Aged,
pubmed-meshheading:11753949-Aged, 80 and over,
pubmed-meshheading:11753949-Carcinogenicity Tests,
pubmed-meshheading:11753949-DNA Methylation,
pubmed-meshheading:11753949-Disease-Free Survival,
pubmed-meshheading:11753949-Female,
pubmed-meshheading:11753949-Genes, ras,
pubmed-meshheading:11753949-Humans,
pubmed-meshheading:11753949-Lymphatic Metastasis,
pubmed-meshheading:11753949-Male,
pubmed-meshheading:11753949-Middle Aged,
pubmed-meshheading:11753949-Mutation,
pubmed-meshheading:11753949-Neoplasm Staging,
pubmed-meshheading:11753949-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:11753949-Promoter Regions, Genetic,
pubmed-meshheading:11753949-Stomach Neoplasms
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pubmed:year |
2001
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pubmed:articleTitle |
Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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