Source:http://linkedlifedata.com/resource/pubmed/id/11753907
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2001-12-25
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pubmed:abstractText |
Post-orthotopic liver transplantation (OLT) recurrence of hepatitis C is virtually universal, but histological progression of disease is not. This study examines long-term clinical and liver histological features at and after OLT to elucidate factors predictive of hepatitis C recurrence and progression after OLT. A blinded retrospective review of clinical, serological, and histopathologic features of 65 patients who underwent OLT for hepatitis C and Non A Non B hepatitis was conducted. Histological findings of recurrent hepatitis C and progression (fibrosis, >or= grade 2 by last follow-up) were correlated with clinical parameters. Histological recurrence of hepatitis C was seen in 43 of 65 patients, with progression in 19 patients. Histological findings in the native liver and post-OLT biopsy specimen at the time of recurrence showed no correlation with hepatitis C recurrence and progression. Patients treated with azathioprine (AZA)-containing immunosuppressive regimens experienced less recurrence (6 of 17 v 37 of 48 patients; P < .005) and progression (1 of 17 v 18 of 48 patients; P = .014) than those without AZA as part of their immunosuppressive regimen. No difference was seen between patients treated with cyclosporine versus those administered FK506 (P > .05). Histological recurrence of hepatitis C after OLT is seen in 66% of patients with progressive disease and 29% of all patients. The grade of inflammation in the native liver at the time of OLT and time of recurrence is not predictive of progression. AZA-containing regimens reduce histological recurrence and progression of hepatitis C in post-OLT patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1527-6465
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1056-63
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11753907-Adolescent,
pubmed-meshheading:11753907-Adult,
pubmed-meshheading:11753907-Aged,
pubmed-meshheading:11753907-Azathioprine,
pubmed-meshheading:11753907-Disease Progression,
pubmed-meshheading:11753907-Female,
pubmed-meshheading:11753907-Hepatitis C,
pubmed-meshheading:11753907-Humans,
pubmed-meshheading:11753907-Immunosuppression,
pubmed-meshheading:11753907-Liver,
pubmed-meshheading:11753907-Liver Transplantation,
pubmed-meshheading:11753907-Male,
pubmed-meshheading:11753907-Middle Aged,
pubmed-meshheading:11753907-Postoperative Period,
pubmed-meshheading:11753907-Recurrence
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pubmed:year |
2001
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pubmed:articleTitle |
Histological recurrence and progression of hepatitis C after orthotopic liver transplantation: influence of immunosuppressive regimens.
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pubmed:affiliation |
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, USA.
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pubmed:publicationType |
Journal Article
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