Source:http://linkedlifedata.com/resource/pubmed/id/11751032
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-12-25
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| pubmed:abstractText |
Stimulant-dependent subjects show dysfunctions in decision-making similar to those seen in subjects with ventromedial prefrontal cortex lesions. Studies of drug craving, reward association, and decision-making have implicated dysfunctions of the dorsolateral and orbitofrontal cortex as a key neural substrate in subjects with stimulant dependence. Here, a functional magnetic resonance imaging (fMRI) study was carried out to determine the relationship between decision-making dysfunction and neural activation in different prefrontal areas. This investigation tested the behavioral hypothesis that methamphetamine-dependent subjects in early sustained remission show decision-making dysfunctions that are consistent with an increased reliance on stimulus-contingent response selection. It was hypothesized that these decision-making dysfunctions are due to differences in task-related activation in the dorsolateral and ventromedial prefrontal cortex. Ten methamphetamine-dependent subjects were compared with ten age- and education-matched controls performing a two-choice prediction task and a two-choice response task during a fMRI session. Response bias, latency, and mutual information measures assessing the underlying strategies of the decision-making sequences were obtained. First, methamphetamine-dependent subjects were more influenced by the immediately preceding outcome during the two-choice prediction task relative to normal comparison subjects. Second, methamphetamine-dependent subjects activated less dorsolateral prefrontal cortex (BA 9) and failed to activate ventromedial cortex (BA 10,11) during the two-choice prediction task compared with the two-choice response task. These results support the basic hypothesis that stimulant-dependent subjects exhibit fundamental cognitive deficits during decision-making that are consistent with both orbitofrontal and dorsolateral prefrontal dysfunction.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0893-133X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
53-63
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| pubmed:dateRevised |
2011-5-18
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| pubmed:meshHeading |
pubmed-meshheading:11751032-Adult,
pubmed-meshheading:11751032-Amphetamine-Related Disorders,
pubmed-meshheading:11751032-Behavior,
pubmed-meshheading:11751032-Female,
pubmed-meshheading:11751032-Functional Laterality,
pubmed-meshheading:11751032-Humans,
pubmed-meshheading:11751032-Magnetic Resonance Imaging,
pubmed-meshheading:11751032-Male,
pubmed-meshheading:11751032-Methamphetamine,
pubmed-meshheading:11751032-Middle Aged,
pubmed-meshheading:11751032-Prefrontal Cortex,
pubmed-meshheading:11751032-Psychiatric Status Rating Scales,
pubmed-meshheading:11751032-Psychomotor Performance,
pubmed-meshheading:11751032-Reaction Time
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects.
|
| pubmed:affiliation |
Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, San Diego, CA 92093-0603, USA. martin@mag.ucsd.edu
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|