rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
9297
|
pubmed:dateCreated |
2001-12-18
|
pubmed:abstractText |
The newly discovered SEN D and SEN H viruses are transmitted parenterally and can cause post-transfusion hepatitis. We assessed whether coinfection of patients with chronic hepatitis C and SEN D or SEN H correlates with the outcome of treatment with interferon and ribavirin. Of 31 patients with hepatitis C studied, six were positive for SEN D and seven for SEN H (one was positive for both). All of those positive for SEN D and five of those positive for SEN H failed to respond to therapy. Overall response (RNA titre and alanine aminotransferase concentration after treatment) was lower in SEN-infected patients than uninfected patients (p=0.025). We conclude that coinfection with SEN viruses is frequent in chronic hepatitis C patients and might adversely affect the outcome of treatment with interferon and ribavirin.
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pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0140-6736
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
8
|
pubmed:volume |
358
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1961-2
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:11747922-Alanine Transaminase,
pubmed-meshheading:11747922-Antiviral Agents,
pubmed-meshheading:11747922-DNA Primers,
pubmed-meshheading:11747922-DNA Virus Infections,
pubmed-meshheading:11747922-DNA Viruses,
pubmed-meshheading:11747922-Female,
pubmed-meshheading:11747922-Hepatitis C, Chronic,
pubmed-meshheading:11747922-Humans,
pubmed-meshheading:11747922-Interferon-alpha,
pubmed-meshheading:11747922-Liver Diseases,
pubmed-meshheading:11747922-Male,
pubmed-meshheading:11747922-Polymerase Chain Reaction,
pubmed-meshheading:11747922-RNA, Viral,
pubmed-meshheading:11747922-Recombinant Proteins,
pubmed-meshheading:11747922-Ribavirin,
pubmed-meshheading:11747922-Sequence Analysis, DNA,
pubmed-meshheading:11747922-Treatment Outcome
|
pubmed:year |
2001
|
pubmed:articleTitle |
Effect on treatment outcome of coinfection with SEN viruses in patients with hepatitis C.
|
pubmed:publicationType |
Letter
|